Epigenome-wide association studies identify DNA methylation associated with kidney function
Chronic kidney disease (CKD) is defined by reduced estimated glomerular filtration rate
(eGFR). Previous genetic studies have implicated regulatory mechanisms contributing to …
(eGFR). Previous genetic studies have implicated regulatory mechanisms contributing to …
DNA methylation profile associated with rapid decline in kidney function: findings from the CRIC study
MR Wing, JM Devaney, MM Joffe, D Xie… - Nephrology Dialysis …, 2014 - academic.oup.com
Background Epigenetic mechanisms may be important in the progression of chronic kidney
disease (CKD). Methods We studied the genome-wide DNA methylation pattern associated …
disease (CKD). Methods We studied the genome-wide DNA methylation pattern associated …
DNA hypermethylation and DNA hypomethylation is present at different loci in chronic kidney disease
LJ Smyth, GJ McKay, AP Maxwell, AJ McKnight - Epigenetics, 2014 - Taylor & Francis
Genetic risk factors for chronic kidney disease (CKD) are being identified through
international collaborations. By comparison, epigenetic risk factors for CKD have only …
international collaborations. By comparison, epigenetic risk factors for CKD have only …
DNA methylation markers for kidney function and progression of diabetic kidney disease
Epigenetic markers are potential biomarkers for diabetes and related complications. Using a
prospective cohort from the Hong Kong Diabetes Register, we perform two independent …
prospective cohort from the Hong Kong Diabetes Register, we perform two independent …
Meta-analyses identify DNA methylation associated with kidney function and damage
Chronic kidney disease is a major public health burden. Elevated urinary albumin-to-
creatinine ratio is a measure of kidney damage, and used to diagnose and stage chronic …
creatinine ratio is a measure of kidney damage, and used to diagnose and stage chronic …
Assessment of differentially methylated loci in individuals with end-stage kidney disease attributed to diabetic kidney disease: an exploratory study
Background A subset of individuals with type 1 diabetes mellitus (T1DM) are predisposed to
developing diabetic kidney disease (DKD), the most common cause globally of end-stage …
developing diabetic kidney disease (DKD), the most common cause globally of end-stage …
Systematic integrated analysis of genetic and epigenetic variation in diabetic kidney disease
Poor metabolic control and host genetic predisposition are critical for diabetic kidney
disease (DKD) development. The epigenome integrates information from sequence …
disease (DKD) development. The epigenome integrates information from sequence …
DNA methylation profiling identifies epigenetic differences between diabetes patients with ESRD and diabetes patients without nephropathy
C Sapienza, J Lee, J Powell, O Erinle, F Yafai… - Epigenetics, 2011 - Taylor & Francis
We identified potential epigenetic biomarkers for chronic kidney disease progression by
comparing site-specific DNA methylation levels in more than 14,000 genes between African …
comparing site-specific DNA methylation levels in more than 14,000 genes between African …
Genome-wide DNA methylation analysis for diabetic nephropathy in type 1 diabetes mellitus
CG Bell, AE Teschendorff, VK Rakyan… - BMC medical …, 2010 - Springer
Background Diabetic nephropathy is a serious complication of diabetes mellitus and is
associated with considerable morbidity and high mortality. There is increasing evidence to …
associated with considerable morbidity and high mortality. There is increasing evidence to …
Cytosine methylation predicts renal function decline in American Indians
C Qiu, RL Hanson, G Fufaa, S Kobes, C Gluck… - Kidney International, 2018 - Elsevier
Diabetic nephropathy accounts for most of the excess mortality in individuals with diabetes,
but the molecular mechanisms by which nephropathy develops are largely unknown. Here …
but the molecular mechanisms by which nephropathy develops are largely unknown. Here …