Low molecular weight thiol-containing compounds have an essential role in many
biochemical and pharmacological reactions due to the ease with each they are oxidized …

The mechanisms of thiol metabolism and chemistry have particular relevance to both
cellular defenses against toxicant exposure and to redox signaling. Here, we will focus on …

This review is the introduction to a special issue concerning, glutathione (GSH), the most
abundant low molecular weight thiol compound synthesized in cells. GSH plays critical roles …

Glutathione (GSH) is the major cellular thiol participating in cellular redox reactions and
thioether formation. This article serves as introduction to the FRBM Forum on glutathione …

Glutathione represents the major low molecular weight antioxidant redox recycling thiol in
mammalian cells and plays a central role in the cellular defence against oxidative damage …

Glutathione (GSH) provides a major source of thiol homeostasis critical to the maintenance
of a reduced cellular environment that is conducive to cell survival. Mammals have …

Reduced glutathione (GSH) is the most prevalent non-protein thiol in animal cells. Its de
novo and salvage synthesis serves to maintain a reduced cellular environment and the …

Glutathione (GSH) is the main intracellular thiol antioxidant, and as such participates in a
number of cellular antitoxic and defensive functions. Nevertheless, non-antioxidant functions …

Publisher Summary The thiol redox status of intracellular and extracellular compartments is
critical in the determination of protein structure, regulation of enzyme activity, and control of …

Helmut Sies is one of the leading investigators in the multiple roles of glutathione (GSH) in
biology. He has pioneered work on the role of GSH in preventing oxidative stress, in …