Human pre-implantation embryonic development involves extensive changes in chromatin
structure and transcriptional activity. Here, we report on LiCAT-seq, a technique that enables …

How the chromatin regulatory landscape in the inner cell mass cells is established from
differentially packaged sperm and egg genomes during preimplantation development is …

Cis-regulatory elements regulate gene expression and lineage specification. However, the
potential regulation of cis-elements on mammalian embryogenesis remains largely …

In mammals, extensive chromatin reorganization is essential for reprogramming terminally
committed gametes to a totipotent state during preimplantation development. However, the …

Upon fertilization, drastic chromatin reorganization occurs during preimplantation
development. However, the global chromatin landscape and its molecular dynamics in this …

Implantation is a milestone event during mammalian embryogenesis. Implantation failure is
a considerable cause of early pregnancy loss in humans. Owing to the difficulty of obtaining …

DNA methylation, chromatin states and their interrelationships represent critical epigenetic
information, but these are largely unknown in human early embryos. Here, we apply single …

Extensive epigenetic reprogramming occurs during preimplantation embryo development.
However, it remains largely unclear how the drastic epigenetic reprogramming contributes to …

The dynamics of the chromatin regulatory landscape during human early embryogenesis
remains unknown. Using DNase I hypersensitive site (DHS) sequencing, we report that the …

Chromatin reorganization governs the regulation of gene expression during preimplantation
development. However, the landscape of chromatin dynamics in this period has not been …