Aging-induced memory impairment is closely associated with oxidative stress. D-Galactose
(D-gal) evokes severe oxidative stress and mimics normal aging in animals. Curcumin, a …

Previously, we observed curcumin improves aging-associated memory impairment in d-
galactose (D-gal) and normal-aged (NA) mice. Evidence showed that multiple agents can be …

Abstract Background Curcumin (Curcuma longa) is a well-known medicinal plant that
induces autophagy in various model species, helping maintain cellular homeostasis. Its role …

Abstract d-galactose has been considered a senescent model for age-related
neurodegenerative disease. It induces oxidative stress which triggers memory impairment …

D-galactose (D-gal) administration causes oxidative disorder and is widely utilized in aging
animal models. Therefore, we subcutaneously injected D-gal at 200 mg/kg BW dose to …

Brain senescence plays an important role in cognitive dysfunction and neurodegenerative
disorders. Curcumin was reported to have beneficial effect against several …

Melatonin acts as a pleiotropic agent in various age‐related neurodegenerative diseases. In
this study, we examined the underlying neuroprotective mechanism of melatonin against D …

RESULTS Cur, Hes, and their combination improved neuron length and cellular senescence
by decreasing the number of β-gal stained cells, down-regulated expression of p16 and p21 …

Oxidative stress is known to be associated with various age-related diseases. D-galactose
(D-gal) has been considered a senescent model which induces oxidative stress response …

Objective (s) Accumulating evidence has suggested that oxidative stress and apoptosis are
involved in the aging process. d‐galactose (gal) has been reported to cause symptoms of …