Maintaining proper energy balance in mammals entails intimate crosstalk between various
tissues and organs. These inter-organ communications are mediated, to a great extent, by …

Adipose tissue-derived adipokines play important roles in controlling systemic insulin
sensitivity and energy balance. Our recent efforts to identify novel metabolic mediators …

Adipose tissue-derived adipokines are an important class of secreted metabolic regulators
that mediate tissue cross-talk to control systemic energy balance. We recently described …

C1q/TNF-related proteins (CTRPs) are a family of secreted regulators of glucose and lipid
metabolism. Here, we describe CTRP11, a novel and phylogenetically conserved member …

Despite the prevalence of insulin resistance and type 2 diabetes mellitus, their underlying
mechanisms remain incompletely understood. Many secreted endocrine factors and the …

CTRP9 is a secreted multimeric protein of the C1q family and the closest paralog of the
insulin-sensitizing adipokine, adiponectin. The metabolic function of this adipose tissue …

Transgenic overexpression of CTRP9, a secreted hormone downregulated in obesity,
confers striking protection against diet-induced obesity and type 2 diabetes. However, the …

As the largest endocrine organ, adipose tissue secretes many bioactive molecules that
circulate in blood, collectively termed adipokines. Efforts to identify such metabolic …

Adiponectin is a major insulin-sensitizing, multimeric hormone derived from adipose tissue
that acts on muscle and liver to regulate whole-body glucose and lipid metabolism. Here, we …

The insulin-sensitizing hormone, adiponectin, belongs to the expanding C1q/TNF (tumour
necrosis factor) family of proteins. We recently identified a family of adiponectin paralogues …