The effectiveness of chemotherapy is one of the main challenges in cancer treatment and
resistance to classic drugs and traditional treatment processes is an obstacle to this goal …

Drug resistance is a complex phenomenon that frequently develops as a failure to
chemotherapy during cancer treatment. Malignant cells increasingly generate resistance to …

Inherent and acquired resistance pathways account for the high rate of failure in cancer
chemotherapy. The mechanisms or pathways mediating resistance may be classified as …

Cancer cell resistance to chemotherapy is still a heavy burden that impairs treatment of
cancer patients. Both intrinsic and acquired resistance results from the numerous genetic …

Resistance to chemotherapy limits the effectiveness of anti‐cancer drug treatment. Tumours
may be intrinsically drug‐resistant or develop resistance to chemotherapy during treatment …

Cancer therapy has advanced from tradition chemotherapy methods to targeted therapy,
novel drug delivery mechanisms, combination therapies etc. Although several novel …

It is generally accepted that recent advances in anticancer agents have contributed
significantly to the improvement of both the disease-free survival and quality of life in cancer …

Cancer is the second leading cause of death in the US. Current major treatments for cancer
management include surgery, cytotoxic chemotherapy, targeted therapy, radiation therapy …

Cancer is one of the main causes of death worldwide. Despite the significant development of
methods of cancer healing during the past decades, chemotherapy still remains the main …

The success of current treatment strategies is limited by the development of therapy
resistance as evidenced by recurrence of the primary tumor or distant metastasis …