Increased tissue-level storage modulus and hardness with age in male cortical bone and its association with decreased fracture toughness

RC Singleton, GM Pharr, JS Nyman - Bone, 2021 - Elsevier
The incidence of bone fracture increases with age, due to both declining bone quantity and
quality. Toward the goal of an improved understanding of the causes of the age-related …

Viscoelastic properties of human cortical bone tissue depend on gender and elastic modulus

Z Wu, TC Ovaert, GL Niebur - Journal of Orthopaedic Research, 2012 - Wiley Online Library
Bone exhibits rate‐dependent failure behavior, suggesting that viscoelasticity is a factor in
the damage and fracture of bone. Microdamage initiates at scales below the macroscopic …

Tissue-level mechanical properties of bone contributing to fracture risk

JS Nyman, M Granke, RC Singleton… - Current osteoporosis …, 2016 - Springer
Tissue-level mechanical properties characterize mechanical behavior independently of
microscopic porosity. Specifically, quasi-static nanoindentation provides measurements of …

Role of microstructure in the aging-related deterioration of the toughness of human cortical bone

RK Nalla, JJ Kruzic, JH Kinney, M Balooch… - Materials Science and …, 2006 - Elsevier
The aging-related deterioration of the fracture properties of bone, coupled with higher life
expectancy, is responsible for increasing incidence of bone fracture in the elderly; …

Changes in the fracture toughness of bone may not be reflected in its mineral density, porosity, and tensile properties

XD Wang, NS Masilamani, JD Mabrey, ME Alder… - Bone, 1998 - Elsevier
Age-related changes in the skeleton often lead to an increase in the susceptibility of bone to
fracture. Such changes most likely occur in the constituents of bone, namely, the mineral and …

Microstructural heterogeneity and the fracture toughness of bone

JB Phelps, GB Hubbard, X Wang… - Journal of biomedical …, 2000 - Wiley Online Library
Age‐related changes in the skeleton often lead to an increase in the susceptibility of bone to
fracture. The purpose of this study was to determine whether differences in material …

Changes in the stiffness, strength, and toughness of human cortical bone with age

P Zioupos, JD Currey - Bone, 1998 - Elsevier
Aging adversely affects the elastic and ultimate properties of human cortical bone as seen in
uniaxial tests in quasi static loading, high strain rate impact or fatigue. Little is known about …

Intrinsic material property differences in bone tissue from patients suffering low-trauma osteoporotic fractures, compared to matched non-fracturing women

S Vennin, A Desyatova, JA Turner, PA Watson… - Bone, 2017 - Elsevier
Osteoporotic (low-trauma) fractures are a significant public health problem. Over 50% of
women over 50 yrs. of age will suffer an osteoporotic fracture in their remaining lifetimes …

Effect of aging on the toughness of human cortical bone: evaluation by R-curves

RK Nalla, JJ Kruzic, JH Kinney, RO Ritchie - Bone, 2004 - Elsevier
Age-related deterioration of the fracture properties of bone, coupled with increased life
expectancy, is responsible for increasing incidence of bone fracture in the elderly, and …

Anisotropy of age-related toughness loss in human cortical bone: a finite element study

A Ural, D Vashishth - Journal of biomechanics, 2007 - Elsevier
A mechanistic understanding of the role of bone quality on fracture processes is essential for
determining the underlying causes of age-related changes in the mechanical response of …