In a prospective-longitudinal study of a representative birth cohort, we tested why stressful
experiences lead to depression in some people but not in others. A functional polymorphism …

The distribution of 5-hydroxyindoleacetic acid (5-HIAA) concentrations in the cerebrospinal
fluid of 68 depressed patients was bimodal. Twenty-nine percent of the patients were in the …

Depressive illness is characterised by periods of depression usually starting in the early
forties. If the patient is not treated the episode will last from six to eighteen months and then …

After the death of a family member or other traumatic event, some people slip into
depression while others bounce back. Now, new findings by an international team of …

Researchers are closely scrutinizing a gene that could explain why some people are
depressed—and also why they don't respond to antidepressant drugs that act on the …

Research suggests that a polymorphism in the promoter region of the serotonin transporter
promoter (5-HTTLPR) interacts with stressful life events to predict depressive onset, with …

In his Perspective “Why stress is bad for your brain”(1), Robert M. Sapolsky concludes that
glucocorticoid (GC) excess, sometimes a result of sustained stress, is a “likely culprit in …

The pathophysiology of depression remains enigmatic, although abnormalities in serotonin
signaling have been implicated. We have found that the serotonin 1B receptor [5 …

The neuromodulator serotonin (5-hydroxytryptamine, 5-HT) has been associated with mood
disorders such as depression, anxiety, and impulsive violence. To define the contribution of …