Polymer coatings to minimize protein adsorption in solid‐state nanopores

S Awasthi, P Sriboonpeng, C Ying… - Small …, 2020 - Wiley Online Library
Nanopore‐based resistive‐pulse recordings represent a promising approach for single‐
molecule biophysics with applications ranging from rapid DNA and RNA sequencing to …

Fluid surface coatings for solid-state nanopores: comparison of phospholipid bilayers and archaea-inspired lipid monolayers

OM Eggenberger, G Leriche, T Koyanagi… - …, 2019 - iopscience.iop.org
In the context of sensing and characterizing single proteins with synthetic nanopores, lipid
bilayer coatings provide at least four benefits: first, they minimize unwanted protein adhesion …

Four aspects about solid‐state nanopores for protein sensing: fabrication, sensitivity, selectivity, and durability

R Hu, X Tong, Q Zhao - Advanced healthcare materials, 2020 - Wiley Online Library
Solid‐state nanopores are a mimic of innate biological nanopores embedded on lipid
membranes. They are fabricated on thin suspended layers of synthetic materials that provide …

Surface coatings for solid-state nanopores

OM Eggenberger, C Ying, M Mayer - Nanoscale, 2019 - pubs.rsc.org
Since their introduction in 2001, solid-state nanopores have been increasingly exploited for
the detection and characterization of biomolecules ranging from single DNA strands to …

Monitoring protein adsorption with solid-state nanopores

DJ Niedzwiecki, L Movileanu - JoVE (Journal of Visualized Experiments), 2011 - jove.com
Solid-state nanopores have been used to perform measurements at the single-molecule
level to examine the local structure and flexibility of nucleic acids 1-6, the unfolding of …

Non-sticky translocation of bio-molecules through Tween 20-coated solid-state nanopores in a wide pH range

X Li, R Hu, J Li, X Tong, JJ Diao, D Yu… - Applied Physics …, 2016 - pubs.aip.org
Nanopore-based sensing technology is considered high-throughput and low-cost for single
molecule detection, but solid-state nanopores have suffered from pore clogging issues. A …

Silver Nanoneedle Probes Enable Sustained DC Current, Single-Channel Resistive Pulse Nanopore Sensing

EA Hussein, RJ White - Analytical Chemistry, 2021 - ACS Publications
Resistive pulse sensing using ion channel proteins (biological nanopores) has been
evolving as a single-molecule approach to detect small biomolecules owing to atomically …

A method for reproducibly preparing synthetic nanopores for resistive‐pulse biosensors

JE Wharton, P Jin, LT Sexton, LP Horne, SA Sherrill… - Small, 2007 - Wiley Online Library
There is increasing interest in using nanopores in synthetic membranes as resistive‐pulse
sensors for biomedical analytes. Analytes detected with prototype artificial‐nanopore …

A generalizable nanopore sensor for highly specific protein detection at single-molecule precision

M Ahmad, JH Ha, LA Mayse, MF Presti… - Nature …, 2023 - nature.com
Protein detection has wide-ranging implications in molecular diagnostics. Substantial
progress has been made in protein analytics using nanopores and the resistive-pulse …

In-Plane, In-Series Nanopores with Circular Cross Sections for Resistive-Pulse Sensing

M Zhang, ZD Harms, T Greibe, CA Starr, A Zlotnick… - ACS …, 2022 - ACS Publications
Resistive-pulse sensing with solid-state nanopores is a sensitive, label-free technique for
analyzing single molecules in solution. To add functionality to resistive-pulse …