A growing amount of evidences indicates that inflammaging–the chronic, low grade
inflammation state characteristic of the elderly–is the result of genetic as well as …

The number of centenarians is growing worldwide. This specific cohort has aroused the
attention of scientists worldwide and is considered one of the most valuable models to study …

Cancer is generally recognized as an age-related disease. In fact, incidence and mortality
rates of most human cancers increase consistently with age up to 90 years, but they plateau …

Aging is characterized by a morpho-functional adaptation, variably affecting major
physiological systems, depending on a complex interaction between genetic, environmental …

For over 10 years we have studied centenarians as a model to address the biological basis
of aging and longevity, with particular attention to immunology and genetics. The most …

Limited evidence exists on the link between inflammation and epigenetic aging. We aimed
to (a) assess the cross-sectional and prospective associations of 22 inflammation-related …

The phenotype of old people is the result of the capability of the body to respond/adapt to
cellular and molecular insults continuously occurring in all tissues and organs (damaging …

Longevity and aging are two sides of the same coin, as they both derive from the interaction
between genetic and environmental factors. Aging is a complex, dynamic biological process …

A large part of the aging phenotype, including immunosenescence, is explained by an
imbalance between inflammatory and anti-inflammatory networks, which results in the low …

At present, individuals can live up to 80–120 years, a time much longer than that of our
ancestors, as a consequence of the improvements in life conditions and medical care. Thus …