Objective: To implement a mendelian randomization (MR) approach to determine whether
type 2 diabetes mellitus (T2D), fasting glucose, fasting insulin, and body mass index (BMI) …

While type 2 diabetes mellitus (T2DM) is commonly considered a putative causal risk factor
for stroke, the effect of stroke on T2DM remains unclear. The intrinsic link underlying T2DM …

2 Stroke February 2018 low frequency and rare mutations, as well as hard-to-detect risk
alleles for specific stroke subtypes and ethnic groups. 12 Formed in 2007, the ISGC was …

Methods In order to identify genetic loci associated with ischemic stroke, we performed a two-
stage genome-wide association study. The first stage consisted of 16,851 cases with state-of …

With a swiftly moving, highly technical field, it helps to have a reliable guide. In this issue of
Stroke, Lanktree et al1 provide a timely overview of genomic analysis applied to stroke. 1 …

Objective We employed Mendelian randomization to explore the effects of genetic
predisposition to type 2 diabetes (T2D), hyperglycemia, insulin resistance, and pancreatic β …

Since the unveiling of the human genome sequence in February, 2001, 1 geneticists have
progressed tremendously in the understanding of what makes an individual so different from …

Stroke is a major cause of mortality and morbidity in both the developed and developing
world. Next generation sequencing (NGS) and multi-omics integrative biology research offer …

The precise pathophysiology of ischaemic stroke is unclear, and a greater understanding of
the different mechanisms that underlie large-artery, cardioembolic and lacunar ischaemic …