Pharmaceutical approaches based on nanotechnologies and the development of eye drops
composed of the mucoadhesive polymers chitosan and hyaluronic acid are emerging …

Management of extraocular disease is mainly limited by the inability to provide long-term
extraocular drug delivery without avoiding the systemic drug exposure and/or affecting the …

Present limitations in the management of extraocular diseases include the inability to
provide long-term extraocular drug delivery without compromising intraocular structures …

The purpose of this review is to provide the reader with an overview of the advances made
in ocular delivery of bioactive molecules by means of chitosan-based nanosystems, and …

Over the last years, the scientific interest about topical ocular delivery targeting the posterior
segment of the eye has been increasing. This is probably due to the fact that this is a non …

Abstract Development of efficient ocular delivery nanosystems remains a major challenge to
achieve sustained therapeutic effect. The purpose of this work was to develop chitosan …

The efficacy of conventional ocular formulations is limited by poor corneal retention and
permeation, resulting in low ocular bioavailability. Mucoadhesive chitosan (CS) …

The objective of the study was to develop chitosan (CH) coated sodium alginate–chitosan
(SA–CH) nanoparticles, ie CH-SA–CH NPs loaded with 5-FU for ophthalmic delivery. Drug …

This paper presents an overview of the potential of chitosan‐based systems for improving
the retention and biodistribution of drugs applied topically onto the eye. Besides its low …

Background: Mucoadhesive drug delivery is a promising strategy to overcome ocular
biopharmaceutical constraints. Objective and methods: Ciprofloxacin HCl-loaded reverse …