Structural characterization of the helicase nsp10 encoded by porcine reproductive and respiratory syndrome virus

Y Shi, X Tong, G Ye, R Xiu, L Li, L Sun, J Shi… - Journal of …, 2020 - Am Soc Microbiol
Currently, an effective therapeutic treatment for porcine reproductive and respiratory
syndrome virus (PRRSV) remains elusive. PRRSV helicase nsp10 is an important …

Helicase of type 2 porcine reproductive and respiratory syndrome virus strain HV reveals a unique structure

C Tang, Z Deng, X Li, M Yang, Z Tian, Z Chen, G Wang… - Viruses, 2020 - mdpi.com
Porcine reproductive and respiratory syndrome virus (PRRSV) is prevalent throughout the
world and has caused great economic losses to the swine industry. Nonstructural protein 10 …

Mutational analysis of the functional sites in porcine reproductive and respiratory syndrome virus non-structural protein 10

Y Zhang, H Li, G Peng, Y Zhang… - Journal of General …, 2015 - microbiologyresearch.org
Porcine reproductive and respiratory syndrome virus (PRRSV) is prevalent throughout the
world and has caused major economic losses to the pig industry. Arterivirus non-structural …

Identification of an intramolecular switch that controls the interaction of helicase nsp10 with membrane-associated nsp12 of porcine reproductive and respiratory …

Y Hu, P Ke, P Gao, Y Zhang, L Zhou, X Ge… - Journal of …, 2021 - Am Soc Microbiol
ABSTRACT A critical step in replication of positive-stranded RNA viruses is the assembly of
replication and transcription complexes (RTC). We have recently mapped the nonstructural …

Functional properties of the predicted helicase of porcine reproductive and respiratory syndrome virus

EM Bautista, KS Faaberg, D Mickelson, ED McGruder - Virology, 2002 - Elsevier
Porcine reproductive and respiratory syndrome virus (PRRSV) is a member of the positive-
strand RNA virus family Arteriviridae. Although considerable research has focused on this …

A dimerization-dependent mechanism drives the endoribonuclease function of porcine reproductive and respiratory syndrome virus nsp11

Y Shi, Y Li, Y Lei, G Ye, Z Shen, L Sun, R Luo… - Journal of …, 2016 - Am Soc Microbiol
Porcine reproductive and respiratory syndrome virus (PRRSV) RNA endoribonuclease
nsp11 belongs to the XendoU superfamily and plays a crucial role in arterivirus replication …

The DEAD-box RNA helicase 5 positively regulates the replication of porcine reproductive and respiratory syndrome virus by interacting with viral Nsp9 in vitro

S Zhao, X Ge, X Wang, A Liu, X Guo, L Zhou, K Yu… - Virus research, 2015 - Elsevier
Abstract The nonstructural protein 9 (Nsp9) of porcine reproductive and respiratory
syndrome virus (PRRSV) has been recognized to play important roles in viral replication …

Crystal structure of porcine reproductive and respiratory syndrome virus leader protease Nsp1α

Y Sun, F Xue, Y Guo, M Ma, N Hao, XC Zhang… - Journal of …, 2009 - Am Soc Microbiol
Porcine reproductive and respiratory syndrome (PRRS) virus (PRRSV), a positive-strand
RNA virus that belongs to the Arteriviridae family of Nidovirales, has been identified as the …

Identification of nonstructural protein 8 as the N-terminus of the RNA-dependent RNA polymerase of porcine reproductive and respiratory syndrome virus

Y Liu, Y Hu, Y Chai, L Liu, J Song, S Zhou, J Su, L Zhou… - Virologica Sinica, 2018 - Springer
Porcine reproductive and respiratory syndrome virus (PRRSV) is a member within the family
Arteriviridae of the order Nidovirales. Replication of this positive-stranded RNA virus within …

Porcine reproductive and respiratory syndrome virus nucleocapsid protein interacts with Nsp9 and cellular DHX9 to regulate viral RNA synthesis

L Liu, J Tian, H Nan, M Tian, Y Li, X Xu… - Journal of …, 2016 - Am Soc Microbiol
Porcine reproductive and respiratory syndrome virus (PRRSV) nucleocapsid (N) protein is
the main component of the viral capsid to encapsulate viral RNA, and it is also a …