Genomic stability depends on an efficient DNA damage repair system to keep the
chromosomes intact. Unrepaired DNA damage not only causes cell cycle arrest, apoptosis …

Dysregulation of DNA damage repair and signalling to cell cycle checkpoints, known as the
DNA damage response (DDR), is associated with a predisposition to cancer and affects …

The DNA damage response (DDR) is a series of pathways and processes required to repair
lesions to DNA. These pathways range from repairing strand breaks to the double helix …

Millions of DNA-damaging lesions occur every day in each cell of our bodies due to various
stresses. The failure to detect and accurately repair these lesions can give rise to cells with …

Simple Summary Cells respond to genotoxic stress through complex protein pathways
called DNA damage response (DDR). These mechanisms ensure the preservation of …

Preservation of genome integrity is an essential process for cell homeostasis. During the
course of life of a single cell, the genome is constantly damaged by endogenous and …

The DNA of all cells is continually under assault from a wide range of DNA-damaging
agents. To counter this threat to their genetic integrity, cells possess systems, collectively …

Despite the progress in targeting particular molecular abnormalities specific to different
cancers (targeted therapy), chemo-and radiotherapies are still the most effective of all …

DNA damage-inducing therapies are of tremendous value for cancer treatment and function
by the direct or indirect formation of DNA lesions and subsequent inhibition of cellular …

The cell death response to DNA damage is discussed in this Perspectives piece with cancer
as the backdrop because DNA damaging agents (DDA) are widely used to treat cancer …