Proinflammatory cytokine interleukin-1 beta (IL-1β) may accumulate in the brain during
status epilepticus, but whether it contributes to the progressive refractoriness of SE remains …

We studied whether pharmacological blockade of the IL-1β-mediated signaling, rapidly
activated in forebrain by epileptogenic injuries, affords neuroprotection in two different rat …

Abstract Interleukin-1β (IL-1β) is associated with seizure-induced neuronal cell death in the
adult brain. The contribution of IL-1β to neuronal injury induced by status epilepticus (SE) in …

Status epilepticus (SE) is one of the most serious manifestations of epilepsy. Systemic
inflammation and damage of blood-brain barrier (BBB) are etiologic cofactors in the …

Interleukin-1β is rapidly synthesized by glia after the induction of seizures. Recent evidence
shows that endogenous IL-1β has proconvulsant actions mediated by interleukin-1 receptor …

Rationale Seizures during status epilepticus (SE) cause neuronal death and induce
cyclooxygenase-2 (COX-2). Pilocarpine-induced SE was used to determine if COX-2 …

Abstract Background Interleukin-1β (IL-1β) increases necrotic neuronal cell death in the CA1
area after induced status epilepticus (SE) in developing rats. However, it remains uncertain …

OBJECTIVE: Refractory status epilepticus is one of the most life-threatening neurological
emergencies and is characterized by high morbidity and mortality. Additionally, the use of …

Background Status epilepticus (SE) is a severe condition that may lead to hippocampal cell
loss and epileptogenesis. Some of the mechanisms associated with SE-induced cell death …

Aims The postictal suppression (PS) is a common and important period following an
epileptic seizure but has not been well studied. This study was designed to determine …