Cellular chaperonin CCTγ contributes to rabies virus replication during infection

J Zhang, X Wu, J Zan, Y Wu, C Ye, X Ruan… - Journal of …, 2013 - Am Soc Microbiol
Rabies, as the oldest known infectious disease, remains a serious threat to public health
worldwide. The eukaryotic cytosolic chaperonin TRiC/CCT complex facilitates the folding of …

The chaperonin CCTα is required for efficient transcription and replication of rabies virus

J Zhang, C Ye, X Ruan, J Zan, Y Xu… - Microbiology and …, 2014 - Wiley Online Library
Negri bodies (NBs) are formed in the cytoplasm of rabies virus (RABV)‐infected cells and
are accompanied by a number of host factors to NBs, in which replication and transcription …

Chaperonin TRiC/CCT participates in mammarenavirus multiplication in human cells via interaction with the viral nucleoprotein

S Sakabe, H Witwit, R Khafaji, B Cubitt… - Journal of …, 2023 - Am Soc Microbiol
The eukaryotic chaperonin containing tailless complex polypeptide 1 ring complex (CCT,
also known as TCP-1 Ring Complex, TRiC/CCT) participates in the folding of 5% to 10% of …

Rabies virus infection induces the formation of stress granules closely connected to the viral factories

J Nikolic, A Civas, Z Lama… - PLoS …, 2016 - journals.plos.org
Stress granules (SGs) are membrane-less dynamic structures consisting of mRNA and
protein aggregates that form rapidly in response to a wide range of environmental cellular …

Proteomic profiling of purified rabies virus particles

Y Zhang, Y Wang, Y Feng, Z Tu, Z Lou, C Tu - Virologica Sinica, 2020 - Springer
While host proteins incorporated into virions during viral budding from infected cell are
known to play essential roles in multiple process of the life cycle of progeny virus, these …

Native mass spectrometry analyses of chaperonin complex TRiC/CCT reveal subunit N-terminal processing and re-association patterns

MP Collier, KB Moreira, KH Li, YC Chen, D Itzhak… - Scientific Reports, 2021 - nature.com
The eukaryotic chaperonin TRiC/CCT is a large ATP-dependent complex essential for
cellular protein folding. Its subunit arrangement into two stacked eight-membered hetero …

The TRiC chaperonin controls reovirus replication through outer-capsid folding

JJ Knowlton, I Fernandez de Castro, AW Ashbrook… - Nature …, 2018 - nature.com
Viruses are molecular machines sustained through a life cycle that requires replication
within host cells. Throughout the infectious cycle, viral and cellular components interact to …

Rabies virus assembly and budding

A Okumura, RN Harty - Advances in virus research, 2011 - Elsevier
Rabies virus (RABV) and other negative-strand RNA viruses are the causes of serious
diseases in humans and animals worldwide. Assembly and budding are important late …

Toll-like receptor 3 (TLR3) plays a major role in the formation of rabies virus Negri Bodies

P Menager, P Roux, F Megret, JP Bourgeois… - PLoS …, 2009 - journals.plos.org
Human neurons express the innate immune response receptor, Toll-like receptor 3 (TLR3).
TLR3 levels are increased in pathological conditions such as brain virus infection. Here, we …

The ATPase ATP6V1A facilitates rabies virus replication by promoting virion uncoating and interacting with the viral matrix protein

X Liu, F Li, J Zhang, L Wang, J Wang, Z Wen… - Journal of biological …, 2021 - ASBMB
Rabies virus (RABV) matrix protein (M) plays crucial roles in viral transcription, replication,
assembly, and budding; however, its function during the early stage of virus replication …