Fragile X syndrome (FXS) is a multi-organ disease that leads to mental retardation, macro-
orchidism in males and premature ovarian insufficiency in female carriers. FXS is also a …

Fragile X syndrome is a common form of mental retardation caused by the absence of the
FMR1 protein, FMRP. Fmr1 knockout mice exhibit a phenotype with some similarities to …

Fragile X syndrome results from the absence of the RNA binding FMR protein. Here, mRNA
was coimmunoprecipitated with the FMRP ribonucleoprotein complex and used to …

Fragile X syndrome is the most common form of inherited mental retardation and is caused
by the absence of expression of the FMR1 gene. The protein encoded by this gene, Fmrp, is …

The Fragile X Syndrome is caused by the loss of function of the FMR1 gene (Pieretti et al.
1991. Cell 66, 817–822; O'Donnell & Warren 2002. Annu Rev Neurosci 25, 315–338] …

Fragile X mental retardation syndrome is one of the most common human genetic diseases.
Patients carry a methylated expansion of a CGG repeat resulting in the silencing of the …

Fragile X syndrome is the result of transcriptional suppression of the gene FMR1 as a result
of a trinucleotide repeat expansion mutation. The normal function of the FMR1 protein …

Fragile X syndrome is one of the most common human genetic diseases and the most
common cause of hereditary mental retardation. The gene that causes frag ile X syndrome …

Fragile X mental retardation protein (FMRP) is the product of the fragile X mental retardation
1 gene (FMR1), a gene that—when epigenetically inactivated by a triplet nucleotide repeat …

Fragile X syndrome is caused by the transcriptional silencing of the FMR1 gene due to a
trinucleotide repeat expansion. The encoded protein, Fmrp, has been found to be a …