Age at menarche is a marker of timing of puberty in females. It varies widely between
individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes …

Age at menarche and age at natural menopause are associated with causes of substantial
morbidity and mortality such as breast cancer and cardiovascular disease. We conducted a …

Pubertal timing varies considerably and is associated with later health outcomes. We
performed multi-ancestry genetic analyses on~ 800,000 women, identifying 1,080 signals for …

Understanding of the genetic regulation of puberty timing has come largely from studies of
rare disorders and population-based studies in women. Here, we report the largest genomic …

To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide
association studies in 87,802 women of European descent, with replication in up to 14,731 …

We conducted a meta-analysis of genome-wide association data to detect genes influencing
age at menarche in 17,510 women. The strongest signal was at 9q31. 2 (P= 1.7× 10− 9) …

Earlier menarche correlates with shorter adult height and higher childhood body fat. We
conducted a genome-wide association study of age at menarche (AAM) on 15,297 Icelandic …

The timing of puberty is highly variable and is associated with long-term health outcomes. To
date, understanding of the genetic control of puberty timing is based largely on studies in …

Little is known about genes regulating male puberty. Further, while many identified pubertal
timing variants associate with age at menarche, a late manifestation of puberty, and body …

The factors that regulate the timing of puberty remain largely elusive, as do the factors that
modulate childhood growth and adult height. However, it is clear that these developmental …