[HTML][HTML] A transient upregulation of glutamine synthetase in the dentate gyrus is involved in epileptogenesis induced by amygdala kindling in the rat
Reduction of glutamine synthetase (GS) function is closely related to established epilepsy,
but little is known regarding its role in epileptogenesis. The present study aimed to elucidate …
but little is known regarding its role in epileptogenesis. The present study aimed to elucidate …
Progressive neuronal activation accompanies epileptogenesis caused by hippocampal glutamine synthetase inhibition
Loss of glutamine synthetase (GS) in hippocampal astrocytes has been implicated in the
causation of human mesial temporal lobe epilepsy (MTLE). However, the mechanism by …
causation of human mesial temporal lobe epilepsy (MTLE). However, the mechanism by …
Alterations in glutamine synthetase activity by FeCl2‐induced focal and kindled amygdaloid seizures
EC Tiffany‐Castiglioni, SL Peterson… - Journal of …, 1990 - Wiley Online Library
The purpose of this study was to determine the effects of two experimental models of chronic
epilepsy in rats on the activity of the astroglial enzyme glutamine synthetase. FeCl2‐induced …
epilepsy in rats on the activity of the astroglial enzyme glutamine synthetase. FeCl2‐induced …
Redistribution of astrocytic glutamine synthetase in the hippocampus of chronic epileptic rats
IE Papageorgiou, S Gabriel, AF Fetani, O Kann… - Glia, 2011 - Wiley Online Library
Glutamine synthetase (GS) is an astrocytic enzyme, which catalyzes the synthesis of
glutamine from glutamate and ammonia. In the central nervous system, GS prevents …
glutamine from glutamate and ammonia. In the central nervous system, GS prevents …
Inhibition of glutamine synthetase in the central nucleus of the amygdala induces anhedonic behavior and recurrent seizures in a rat model of mesial temporal lobe …
SE Gruenbaum, H Wang, HP Zaveri, AB Tang… - Epilepsy & Behavior, 2015 - Elsevier
The prevalence of depression and suicide is increased in patients with mesial temporal lobe
epilepsy (MTLE); however, the underlying mechanism remains unknown. Anhedonia, a core …
epilepsy (MTLE); however, the underlying mechanism remains unknown. Anhedonia, a core …
Glutamine synthetase becomes nitrated and its activity is reduced during repetitive seizure activity in the pentylentetrazole model of epilepsy
HJ Bidmon, B Görg, N Palomero‐Gallagher… - …, 2008 - Wiley Online Library
Purpose: The astrocyte‐specific glutamine synthetase (GS) plays a key role in glutamate
recycling and Gamma‐aminobutyric acid (GABA) metabolism. Changes in the expression or …
recycling and Gamma‐aminobutyric acid (GABA) metabolism. Changes in the expression or …
Altered glutamate metabolism contributes to antiepileptogenic effects in the progression from focal seizure to generalized seizure by low-frequency stimulation in the …
HL Sun, W Zhu, YR Zhang, XH Pan, JR Zhang… - Epilepsy & Behavior, 2017 - Elsevier
As a promising method for treating intractable epilepsy, the inhibitory effect of low-frequency
stimulation (LFS) is well known, although its mechanisms remain unclear. Excessive levels …
stimulation (LFS) is well known, although its mechanisms remain unclear. Excessive levels …
Roles of glutamine synthetase inhibition in epilepsy
T Eid, K Behar, R Dhaher, AV Bumanglag… - Neurochemical …, 2012 - Springer
Abstract Glutamine synthetase (GS, EC 6.3. 1.2) is a ubiquitous and highly
compartmentalized enzyme that is critically involved in several metabolic pathways in the …
compartmentalized enzyme that is critically involved in several metabolic pathways in the …
Pretreatment with a glutamine synthetase inhibitor MSO delays the onset of initial seizures induced by pilocarpine in juvenile rats
MJ Pawlik, M Obara-Michlewska, MP Popek… - Brain research, 2021 - Elsevier
The contribution of glutamatergic transmission to generation of initial convulsive seizures
(CS) is debated. We tested whether pretreatment with a glutamine synthetase (GS) inhibitor …
(CS) is debated. We tested whether pretreatment with a glutamine synthetase (GS) inhibitor …
Effects of site-specific infusions of methionine sulfoximine on the temporal progression of seizures in a rat model of mesial temporal lobe epilepsy
Glutamine synthetase (GS) in astrocytes is critical for metabolism of glutamate and ammonia
in the brain, and perturbations in the anatomical distribution and activity of the enzyme are …
in the brain, and perturbations in the anatomical distribution and activity of the enzyme are …