To define the cellular composition and architecture of cutaneous squamous cell carcinoma
(cSCC), we combined single-cell RNA sequencing with spatial transcriptomics and …

Spatial transcriptomics, with other spatial technologies, has enabled scientists to dissect the
organization and interaction of different cell types within the tumor microenvironment. We …

The emergent field of digital pathology employing automated image analysis techniques is
to revolutionize traditional pathology at the center of clinical diagnostics. Histological images …

Our understanding of how human skin cells differ according to anatomical site and tumour
formation is limited. To address this, we have created a multiscale spatial atlas of healthy …

Cutaneous squamous cell carcinoma (cSCC) is a serious public health problem due to its
high incidence and metastatic potential. It may progress from actinic keratosis (AK), a …

There is increasing evidence that the spatial organization of cells within the tumor-immune
microenvironment (TiME) of solid tumors influences survival and response to therapy in …

Cancer-associated fibroblasts (CAFs) are a heterogeneous cell population that plays a
crucial role in remodeling the tumor microenvironment (TME). Here, through the integrated …

The diverse malignant, stromal, and immune cells in tumors affect growth, metastasis, and
response to therapy. We profiled transcriptomes of∼ 6,000 single cells from 18 head and …

Biomarker assessments of tumor specimens is widely used in cancer research to audit tumor
cell intrinsic as well as tumor cell extrinsic features including the diversity of immune …

Cancers are characterized by extensive heterogeneity that occurs intratumorally, between
lesions, and across patients. To study cancer as a complex biological system …