Cellular identity is ultimately dictated by the interaction of transcription factors with regulatory
elements (REs) to control gene expression. Advances in epigenome profiling techniques …

Transcription factors (TFs) and their specific interactions with targets are crucial for
specifying gene-expression programs. To gain insights into the transcriptional regulatory …

Background Genome-wide approaches have begun to reveal the transcriptional networks
responsible for pluripotency in embryonic stem (ES) cells. Chromatin Immunoprecipitation …

The use of whole-genome pooled shRNA libraries in loss-of-function screening in tissue
culture models provides an effective means to identify novel factors acting in pathways of …

Embryonic stem cells (ESCs) are derived from the preimplantation embryo and can
differentiate into virtually any other cell type (termed pluripotency), which is governed by …

Transcriptional regulation is a pivotal process that confers cellular identity and modulates
the biological activities within a cell. In embryonic stem cells (ESCs), the intricate interplay …

Human embryonic stem cells (hESCs) hold great promise for regenerative medicine
because they can undergo unlimited self-renewal and retain the capability to differentiate …

Embryonic stem cells (ESCs) are defined by their simultaneous capacity for limitless self-
renewal and the ability to specify cells borne of all germ layers. The regulation of ESC …

The chromatin state of pluripotency genes has been studied extensively in embryonic stem
cells (ESCs) and differentiated cells, but their potential interactions with other parts of the …

Pluripotency is a crucial feature of pluripotent stem cells, which are regulated by the core
pluripotency network consisting of key transcription factors and signaling molecules …