Aicardi-Goutières syndrome (AGS), a hereditary autoimmune disease, clinically and
biochemically overlaps with systemic lupus erythematosus (SLE) and, like SLE, is …

SAMHD1 is a host restriction factor for human immunodeficiency virus 1 (HIV‐1) in cultured
human cells. SAMHD1 mutations cause autoimmune Aicardi‐Goutières syndrome and are …

SAMHD1 is a restriction factor for HIV-1 infection. SAMHD1 mutations cause the
autoinflammatory Aicardi-Goutières syndrome that is characterized by chronic type I …

Mutations in the human SAMHD1 gene are known to correlate with the development of the
Aicardi–Goutières syndrome (AGS), which is an inflammatory encephalopathy that exhibits …

Macrophages are susceptible to human immunodeficiency virus type 1 (HIV-1) infection
despite abundant expression of antiviral proteins. Perhaps the most important antiviral …

Sterile alpha motif and HD-domain–containing protein 1 (SAMHD1) blocks replication of
retroviruses and certain DNA viruses by reducing the intracellular dNTP pool. SAMHD1 has …

Abstract Background Type I interferon (IFN) treatment of some cells, including dendritic cells,
macrophages and monocytic THP-1 cells, restricts HIV-1 infection and prevents viral cDNA …

SAMHD1 is a type I interferon (IFN) inducible host innate immunity restriction factor that
inhibits an early step of the viral life cycle. The underlying mechanisms of SAMHD1 …

Myeloid blood cells are largely resistant to infection with human immunodeficiency virus type
1 (HIV-1). Recently, it was reported that Vpx from HIV-2/SIVsm facilitates infection of these …

Background The restriction factor SAMHD1 regulates intracellular nucleotide level by
degrading dNTPs and blocks the replication of retroviruses and DNA viruses in non-cycling …