Introduction We sought to examine the genetic overlap between vascular pathologies and
Alzheimer's disease (AD) dementia, and the potential mediating role of vascular pathologies …

In recent years, it is becoming apparent that genes may play an important role in the
development of late-onset Alzheimer's disease (LOAD), and genetic studies could unravel …

Evidence suggests the important role of vascular factors both in vascular dementia (VaD)
and Alzheimer disease (AD) pathogenesis. However, the relationship between …

Abstract Introduction Apolipoprotein E (APOE) is a susceptibility gene for late-onset
Alzheimer's disease neuropathology; less is known about the relationship between APOE …

Background: Dementia severity can be modeled as the construct δ, representing the
“cognitive correlates of functionalstatus.” Objective: We recently validated a model for …

Vascular dementia is the second common cause of dementia, only second to Alzheimer's
disease in later life. The Apolipoprotein E (ApoE) gene polymorphism as a risk factor in …

Abstract Background: The APOE Ε4 allele is an established risk factor for Alzheimer's
disease, but reports of its association with vascular dementia (VaD) have been inconsistent …

Objective The purpose of this study was to infer causal relationships between 22 previously
reported risk factors for Alzheimer's disease (AD) and the “AD phenome”: AD, AD age of …

Vascular cognitive impairment (VCI), including vascular dementia, is the second most
common dementia after Alzheimer's disease. Despite its prevalence, the genetic etiology of …

Background/Aims: Genetic risk factors have not been clearly established for vascular
dementias (VaD) related to stroke and cerebrovascular disease. Methods: Samples were …