Naive T lymphocytes travel to T-cell areas of secondary lymphoid organs in search of
antigen presented by dendritic cells,. Once activated, they proliferate vigorously, generating …

CCR7 is only half the story, because cells first adhere to the walls of the lymph-node vessels
using a molecule called L-selectin. So, the 'combination code'for entry of T cells to normal …

AN important process in the immune response is the migration of different populations of
lymphocytes at the proper time to sites of antigenic challenge. Although several …

It is thought that immunity depends on naïve CD4 T cells that proliferate in response to
microbial antigens,,,, differentiate into memory cells that produce anti-microbial …

Lymphocytes that are responsible for regional (tissue-specific) immunity home from the
blood to the intestines, inflamed skin or other sites through a multistep process involving …

A long-standing paradox in cellular immunology concerns the conditional requirement for
CD4+ T-helper (TH) cells in the priming of cytotoxic CD8+ T lymphocyte (CTL) responses in …

Memory CD8 T cells that circulate in the blood and are present in lymphoid organs are an
essential component of long-lived T cell immunity. These memory CD8 T cells remain …

A hallmark of adaptive immunity is the generation of memory T cells that confer long-lived,
antigen-specific protection against repeat challenges by pathogens,,,,. Understanding the …

Memory CD8 T cells, generated by natural pathogen exposure or intentional vaccination,
protect the host against specific viral infections. It has long been proposed that the number of …

Memory T cells can be divided into central memory T cell (TCM cell) and effector memory T
cell (TEM cell) subsets based on homing characteristics and effector functions. Whether TEM …