Biological aging is characterized by a progressive decline in physiological function from
molecular to organismal levels, manifesting through adaptive transcriptional networks. We …

Aging is characterized by the interlocking decay of biological functions over time.
Microarrays have been successful in elucidating some of the genome-wide changes that …

Aging is a complex process influenced by a wide range of environmental and molecular
factors. Despite this complexity, individuals tend to age in highly similar ways, leading to the …

Aging is a complex process that can be characterized by functional and cognitive decline in
an individual. Aging can be assessed based on the functional capacity of vital organs and …

Aging can be defined as a process of progressive decline in the physiological capacity of an
organism, manifested by accumulated alteration and destabilization at the whole system …

In order to understand changes in gene expression that occur as a result of age, which might
create a permissive or causal environment for age-related diseases, we produced a multi …

Aging involves a progressive decline of metabolic function and an increased incidence of
late-onset degenerative disorders and cancer. To a large extent, these processes are …

Regulation of gene expression allows for cells to execute highly specialized functions and
orchestrate a variety of responses to stimuli. Impaired coordination of gene expression is …

Transcription factors can control cell identity and function in health and disease. However,
how they do so during aging is incompletely explored. Maity and colleagues identify age …

Gene expression alterations occur in all mouse tissues during aging, but recent works
highlight minor rather than major dysregulation amplitude for most genes, questioning …