Single-molecule proteomics based on nanopore technology has made significant advances
in recent years. However, to achieve nanopore sensing with single amino acid resolution …

Nanopore technology has been employed as a powerful tool for DNA sequencing and
analysis. To extend this method to peptide sequencing, a necessary step is to profile …

Nanopore-based single-molecule biosensors have been extensively studied. Protein pores
that have receptors attached to them are target-selective, but their real-time applications are …

Biotechnological innovations have vastly improved the capacity to perform large-scale
protein studies, while the methods we have for identifying and quantifying individual proteins …

Nanopore sensing has attracted much attention as a rapid, simple, and label-free single-
molecule detection technology. To apply nanopore sensing to extensive targets including …

Biological nanopores are emerging as sensitive single-molecule sensors for proteins and
peptides. The heterogeneous charge of a polypeptide chain, however, can complicate or …

Aptamers that undergo conformational changes upon small-molecule recognition have been
shown to gate the ionic flux through nanopores by rearranging the charge density within the …

The ability to sense proteins and protein‐related interactions at the single‐molecule level is
becoming of increasing importance to understand biological processes and diseases better …

Nanopore technology holds remarkable promise for sequencing proteins and peptides. To
achieve this, it is necessary to establish a characteristic profile for each individual amino …

The ability to sequence single protein molecules in their native, full-length form would
enable a more comprehensive understanding of proteomic diversity. Current technologies …