Age‐related degeneration of brain white matter (WM) has received a great deal of attention,
with recent studies demonstrating that such changes are correlated with cognitive decline …

Cerebral white matter (WM) undergoes various degenerative changes with normal aging,
including decreases in myelin density and alterations in myelin structure. We acquired …

The pattern of degenerative changes in the brain white matter (WM) in aging, mild cognitive
impairment (MCI), and Alzheimer's disease (AD) has been under debate. Methods of image …

White matter lesions, typically manifesting as regions of signal intensity abnormality (WMSA)
on MRI, increase in frequency with age. However, the role of this damage in cognitive …

We collected MRI diffusion tensor imaging data from 80 younger (20–32 years) and 63 older
(60–71 years) healthy adults. Tract-based spatial statistics (TBSS) analysis revealed that …

The importance of macrostructural white matter changes, including white matter lesions and
atrophy, in intact brain functioning is increasingly being recognized. Diffusion tensor imaging …

Diffusion tensor imaging (DTI) can detect, in vivo, the directionality of molecular diffusion and
estimate the microstructural integrity of white matter (WM) tracts. In this study, we examined …

Background: Damage to white matter tracts, resulting in “cerebral disconnection,” may
underlie age-related cognitive decline. Methods: Using diffusion tensor MRI (DTI) to …

We examined age-related changes in the cerebral white matter. Structural magnetic
resonance images (MRIs) and diffusion tensor images (DTIs) were acquired from 69 healthy …

White matter (WM) fractional anisotropy (FA) is thought to be related to WM integrity and
decline in FA is often used as an index of decreasing WM health. However, the relationship …