Current literature indicates that elevated IL‐6 serum levels are associated with diseases,
disability and mortality in the elderly. In this paper, we studied the IL‐6 promoter genetic …

Ageing is characterized by a pro-inflammatory status, which could contribute to the onset of
major age-related diseases. Thus, genetic variations in pro-or anti-inflammatory cytokines …

Several studies have assessed changes in frequency of− 174 interleukin (IL)-6 single
nucleotide polymorphism (SNP) with age. If IL-6 tracks with disability and age-related …

Cancer rates increase sharply with age in both sexes, and the majority of cases of cancer
occur in patients over the age of 65 years. However, the incidence and mortality for cancer …

IL-6 in vitro production, as well as the serum/plasma concentration of the cytokine, increase
with age. In the present investigation, a total of 62 individuals (31 males and 31 females) …

There has been increasing interest in research on genetic basis of longevity. Aging is
accompanied by immune deterioration and dysregulation of cytokines. Increased IL-6 …

The ageing process is accompanied by the disregulation of interleukin 2 (IL2) and
interleukin 6 (IL6) production. In our paper, we asked whether the age between 60 and 70 …

High levels of IL-6 are coupled with impaired immune efficiency, morbidity and mortality in
ageing. Elderly men with GG (C−) genotype in− 174 locus of IL-6 promoter are …

Background and aims: Human longevity seems to be directly correlated with optimal
functioning of the immune system, suggesting that some genetic determinants of longevity …

BACKGROUND: The serum concentration of interleukin 6 (IL‐6), a cytokine that plays a
central role in inflammation, increases with age. Because inflammation is a component of …