In eukaryotic cells, transcription activation and repression are regulated by transcription
factors (TFs) and nucleosomes. Although it has been demonstrated that a TF and a …

Here, we show that a nucleosome obstructing transcription from the IFN-β promoter slides in
vivo in response to virus infection, thus exposing the previously masked TATA box and the …

The chromatin landscape and promoter architecture are dominated by the interplay of
nucleosome and transcription factor (TF) binding to crucial DNA sequence elements …

Quantitative understanding of the principles regulating nucleosome occupancy on a
genome-wide level is a central issue in eukaryotic genomics. Here, we address this question …

To investigate the mechanism of SWI/SNF action, we have analyzed the pathway by which
SWI/SNF stimulates formation of transcription factor-bound nucleosome core complexes. We …

The fundamental subunit of chromatin, the nucleosome, is not a static entity but can move
along DNA via either thermal or enzyme-driven movements. Here we have monitored the …

One hallmark of ATP-dependent remodeling complexes is the ability to make nucleosomal
DNA accessible to regulatory factors. We have compared two prominent human ATP …

Transcription factors (TF) bind DNA-target sites within promoters to activate gene
expression. TFs target their DNA-recognition sequences with high specificity by binding with …

While recent experiments revealed that some pioneer transcription factors (TFs) can bind to
their target DNA sequences inside a nucleosome, the binding dynamics of their target …

Regulation of gene expression requires dynamic changes in chromatin, but the nature of
these changes is not well understood. Here, we show that progesterone treatment of …