The KRAS mutation is highly correlated with EGFR alterations in patients with non-small cell lung cancer

MJ Yang, CK Hsu, HJ Chang, LC Yen, DA Tsao… - Fooyin Journal of Health …, 2009 - Elsevier
To understand epidermal growth factor receptor (EGFR) and KRAS alterations among
tissues of lung cancer patients in Taiwan, and to further understand how they are related, we …

Relationship between the mutations of epidermal growth factor receptor gene and k-ras gene and the clinicopathological features of non-small cell lung cancers

J ZHANG, Z LIANG, GAO Jie, T LIU - Medical Journal of Peking …, 2010 - xhyxzz.pumch.cn
Objective To investigate the relationship between the mutations of epidermal growth factor
receptor (EGFR) gene, k-ras gene and clinicopathological characteristics in Chinese …

Potential Clinical Significance of a Plasma-Based KRAS Mutation Analysis in Patients with Advanced Non–Small Cell Lung Cancer

S Wang, T An, J Wang, J Zhao, Z Wang, M Zhuo… - Clinical Cancer …, 2010 - AACR
Purpose: Non–small cell lung cancer (NSCLC) with KRAS mutation may be resistant to
epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI). This study aims to …

Mutational analysis of EGFR and K-RAS genes in lung adenocarcinomas

YH Soung, JW Lee, SY Kim, SH Seo, WS Park… - Virchows Archiv, 2005 - Springer
Both epidermal growth factor receptor (EGFR) and RAS gene mutations contribute to the
development of non-small cell lung cancer (NSCLC). Because RAS is one of the …

Comparison of KRAS and EGFR gene status between primary non-small cell lung cancer and local lymph node metastases: implications for clinical practice

L Sun, Q Zhang, H Luan, Z Zhan, C Wang… - Journal of Experimental & …, 2011 - Springer
Background Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI) have
been widely used for the treatment of non-small cell lung cancer (NSCLC). KRAS and EGFR …

EGFR/KRAS/BRAF Mutations in Primary Lung Adenocarcinomas and Corresponding Locoregional Lymph Node Metastases

K Schmid, N Oehl, F Wrba, R Pirker, C Pirker… - Clinical Cancer …, 2009 - AACR
Purpose: The epidermal growth factor receptor (EGFR) and its downstream factors KRAS
and BRAF are mutated with different frequencies in non–small cell lung cancer and …

Detection and analysis of EGFR and KRAS mutations in the patients with lung squamous cell carcinomas

H Zhang, Y Xinjie, QIN Na, LI Xi, Y Huiyi… - Zhongguo Fei Ai …, 2015 - search.proquest.com
背景与目的 表皮生长因子受体 (epidermal growth factor receptor, EGFR) 突变和 KRAS
基因突变是非小细胞肺癌 (non-small cell lung cancer, NSCLC) 靶向治疗的重要分子标志 …

Distinct Epidermal Growth Factor Receptor and KRAS Mutation Patterns in Non–Small Cell Lung Cancer Patients with Different Tobacco Exposure and …

IYS Tam, LP Chung, WS Suen, E Wang… - Clinical Cancer …, 2006 - AACR
Purpose: This study evaluated the mutational profile of epidermal growth factor receptor
(EGFR) and KRAS in non–small cell lung cancers in Hong Kong and determined their …

Relation of EGFR and KRAS gene mutations with its pathological characteristics in non-small cell lung cancer

S Wang, L Dong, A Liu, Y Xiong… - Chinese Journal of …, 2017 - pesquisa.bvsalud.org
Purpose To investigate the relation of EGFR and KRAS gene mutations with the pathological
characteristics in non-small cell lung cancer (NSCLC). Methods The EGFR and KRAS gene …

Mutational analysis of EGFR and K-RAS in Chinese patients with non-small cell lung cancer

F Liu, B Jiang, SJ Gong, BD Yao, WY Zhang… - Zhonghua yi xue yi …, 2007 - europepmc.org
Objective To investigate gene mutations of the epidermal growth factor receptor (EGFR) and
K-RAS in Chinese non-small cell lung cancers (NSCLCs). Methods Mutations of exons 18 …