Genotoxicity assessment of drinking water disinfection byproducts by DNA damage and repair pathway profiling analysis

J Lan, SM Rahman, N Gou, T Jiang… - … science & technology, 2018 - ACS Publications
Genotoxicity is considered a major concern for drinking water disinfection byproducts
(DBPs). Of over 700 DBPs identified to date, only a small number has been assessed with …

Occurrence and toxicity of disinfection byproducts in European drinking waters in relation with the HIWATE epidemiology study

CH Jeong, ED Wagner, VR Siebert… - … science & technology, 2012 - ACS Publications
The HIWATE (H ealth I mpacts of long-term exposure to disinfection byproducts in drinking
WATE r) project was a systematic analysis that combined the epidemiology on adverse …

CHO cell cytotoxicity and genotoxicity analyses of disinfection by-products: an updated review

ED Wagner, MJ Plewa - Journal of Environmental Sciences, 2017 - Elsevier
The disinfection of drinking water is an important public health service that generates high
quality, safe and palatable tap water. The disinfection of drinking water to reduce waterborne …

Unravelling high-molecular-weight DBP toxicity drivers in chlorinated and chloraminated drinking water: Effect-directed analysis of molecular weight fractions

H Dong, AA Cuthbertson, MJ Plewa… - Environmental …, 2023 - ACS Publications
As disinfection byproducts (DBPs) are ubiquitous sources of chemical exposure in
disinfected drinking water, identifying unknown DBPs, especially unknown drivers of toxicity …

Occurrence, genotoxicity, and carcinogenicity of regulated and emerging disinfection by-products in drinking water: a review and roadmap for research

SD Richardson, MJ Plewa, ED Wagner… - … Research/Reviews in …, 2007 - Elsevier
Disinfection by-products (DBPs) are formed when disinfectants (chlorine, ozone, chlorine
dioxide, or chloramines) react with naturally occurring organic matter, anthropogenic …

Genotoxicity assessment of haloacetaldehyde disinfection byproducts via a simplified yeast-based toxicogenomics assay

B Xue, Q Yang, Y Jin, Q Zhu, J Lan, Y Lin… - Environmental …, 2023 - ACS Publications
Haloacetaldehydes (HALs) represent the third-largest category of disinfection byproducts
(DBPs) in drinking water in terms of weight. As a subset of unregulated DBPs, only a few …

Human cell toxicogenomic analysis of bromoacetic acid: A regulated drinking water disinfection by‐product

MG Muellner, MS Attene‐Ramos… - Environmental and …, 2010 - Wiley Online Library
The disinfection of drinking water is a major achievement in protecting the public health.
However, current disinfection methods also generate disinfection by‐products (DBPs). Many …

Predictive QSAR models for the toxicity of disinfection byproducts

L Qin, X Zhang, Y Chen, L Mo, H Zeng, Y Liang - Molecules, 2017 - mdpi.com
Several hundred disinfection byproducts (DBPs) in drinking water have been identified, and
are known to have potentially adverse health effects. There are toxicological data gaps for …

Fingerprinting the reactive toxicity pathways of 50 drinking water disinfection by-products

D Stalter, E O'Malley, U Von Gunten, BI Escher - Water research, 2016 - Elsevier
A set of nine in vitro cellular bioassays indicative of different stages of the cellular toxicity
pathway was applied to 50 disinfection by-products (DBPs) to obtain a better understanding …

Is genotoxicity associated with disinfection byproducts in potable reuse and conventional drinking water additive?

SS Lau, T Tang, L Odeh, K Bokenkamp… - … & Technology Letters, 2023 - ACS Publications
We have previously shown that the Chinese hamster ovary (CHO) cell chronic cytotoxicity of
disinfection byproducts (DBPs) in a mixture of DBPs is additive, supporting the use of the …