CULLIN 2 (CUL2) is a component of the ElonginB/C-CUL2-RBX-1-Von Hippel-Lindau (VHL)
tumor suppressor complex that ubiquitinates and degrades hypoxia-inducible factor α …

Hypoxia-inducible factor 1α (HIF-1α) degradation under normoxia is critical to modulating
vascular growth. This degradation is mediated during normoxia by the von Hippel–Lindau …

Summary The von Hippel-Lindau tumor suppressor protein (VHL) recruits a Cullin 2 (Cul2)
E3 ubiquitin ligase to downregulate HIF-1α, an essential transcription factor for the hypoxia …

Hypoxia inducible factors (HIF) are candidate transcriptional regulators of vascular
development. Unlike HIF-1α–the founding member of the HIF family–which is expressed …

The von Hippel–Lindau (VHL) tumor suppressor gene encodes a component of a ubiquitin
ligase complex containing elongin B, elongin C, cullin 2, and Rbx1, which acts as a negative …

Hypoxia-inducible factors (HIFs) are transcriptional regulators that mediate the cellular
response to low oxygen levels. By stimulating the expression of angiogenic growth factors …

Hypoxia-inducible factor-1 (HIF-1) controls the expression of a number of genes such as
vascular endothelial growth factor (VEGF) and Erythropoietin in low oxygen conditions …

Hypoxia-inducible factor-1 (HIF-1) mediates transcriptional activation of vascular endothelial
growth factor (VEGF) and other hypoxia-responsive genes. Transgenic expression of a …

Inactivation of the von Hippel‐Lindau (VHL) tumour suppressor gene product pVHL is the
cause of inherited VHL disease and is associated with sporadic kidney cancer. pVHL is …

Although our understanding of the molecular regulation of adult neovascularization has
advanced tremendously, vascular-targeted therapies for tissue ischemia remain suboptimal …