Protective effects of spermidine against cirrhotic cardiomyopathy in bile duct-ligated rats

M Sheibani, S Nezamoleslami… - Journal of …, 2020 - journals.lww.com
Cirrhotic cardiomyopathy is a critical factor that causes morbidity and mortality in crucial
conditions such as liver transplantation. In animal model, the common pathophysiologic …

[HTML][HTML] Silymarin administration attenuates cirrhotic-induced cardiac abnormality in the rats: A possible role of β1-adrenergic receptors and L-type voltage-dependent …

G Bayat, R Mazloom, SA Hashemi… - Iranian Journal of …, 2022 - ncbi.nlm.nih.gov
Background: Cirrhotic cardiomyopathy is a well-recognized cardiac dysfunction in cirrhotic
patients. Studies have confirmed the protective effects of silymarin in different types of …

Cirrhotic Cardiomyopathy Following Bile Duct Ligation in Rats—A Matter of Time?

M Uhlig, M Hein, MA Habigt, RH Tolba… - International journal of …, 2023 - mdpi.com
Cirrhotic patients often suffer from cirrhotic cardiomyopathy (CCM). Previous animal models
of CCM were inconsistent concerning the time and mechanism of injury; thus, the temporal …

[HTML][HTML] Minocycline attenuates cirrhotic cardiomyopathy and portal hypertension in a rat model: Possible involvement of nitric oxide pathway

SE Mousavi, SM Rezayat, M Nobakht… - Iranian Journal of …, 2016 - ncbi.nlm.nih.gov
Objective (s): An increase in nitric oxide (NO) production has been reported in cirrhotic
cardiomyopathy and, portal hypertension. Since minocycline has been shown to inhibit NO …

Preconditioning and anti-apoptotic effects of Metformin and Cyclosporine-A in an isolated bile duct-ligated rat heart

HR Moheimani, T Amiriani, AM Alizadeh, Y Jand… - European Journal of …, 2021 - Elsevier
Despite all previous studies relating to the mechanism of cirrhotic cardiomyopathy (CCM),
the role of cirrhosis on Ischemic Preconditioning (IPC) has not yet been explored. The …

Differential effects of jaundice and cirrhosis on β-adrenoceptor signaling in three rat models of cirrhotic cardiomyopathy

Z Ma, Y Zhang, PM Huet, SS Lee - Journal of hepatology, 1999 - Elsevier
Background/Aims: Attenuated cardiac function has been reported in cirrhosis as well as in
jaundice, but the mechanisms remain unclear. This study aimed to explore the differential …

[HTML][HTML] A study of the cardioprotective effect of spermidine: A novel inducer of autophagy

EM Omar, RS Omar, MS Shoela… - Journal of Physiology …, 2021 - journals.lww.com
Acute myocardial infarction (AMI) is an instant death of cardiomyocytes that ends in a large
mortality worldwide. Thus, there is a great interest to come up with novel protective …

Cardioprotective effect of matrine on isoproterenol-induced cardiotoxicity in rats

X Li, R Zhou, P Zheng, L Yan, Y Wu… - Journal of Pharmacy …, 2010 - academic.oup.com
Objectives This study was designed to explore the effect and mechanism of matrine, an
active component of Chinese traditional medicine, on isoproterenol-induced acute …

Effect of Metformin on Myocardial Injury Induced by Hepatic Ischemia-Reperfusion in Rats

W An, JS Kang - Frontiers in Pharmacology, 2022 - frontiersin.org
Background: There is no effective medication for treatment or prevention of hepatic ischemia-
reperfusion (HIR) injury caused by liver transplantation and hepatectomy. This study aimed …

The possible role of nitric oxide and oxidative stress in the enhanced apoptosis of cardiac cells in cirrhotic rats

H Shafaroodi, M Hashemi, ZN Sharif, L Moezi… - Acta Medica …, 2017 - acta.tums.ac.ir
Cirrhosis has been related with hyperdynamic circulation, manifesting as increased cardiac
output and decreased systemic vascular resistance. In the present study we examined the …