Comprehensive insights into the catalytic mechanism of middle east respiratory syndrome 3C-like protease and severe acute respiratory syndrome 3C-like protease
Coronavirus 3C-like protease (3CLPro) is a highly conserved cysteine protease employing a
catalytic dyad for its functions. 3CLPro is essential to the viral life cycle and, therefore, is an …
catalytic dyad for its functions. 3CLPro is essential to the viral life cycle and, therefore, is an …
Structures of the Middle East respiratory syndrome coronavirus 3C-like protease reveal insights into substrate specificity
D Needle, GT Lountos, DS Waugh - Acta Crystallographica Section D …, 2015 - scripts.iucr.org
Middle East respiratory syndrome coronavirus (MERS-CoV) is a highly pathogenic virus that
causes severe respiratory illness accompanied by multi-organ dysfunction, resulting in a …
causes severe respiratory illness accompanied by multi-organ dysfunction, resulting in a …
Residues on the dimer interface of SARS coronavirus 3C-like protease: dimer stability characterization and enzyme catalytic activity analysis
S Chen, J Zhang, T Hu, K Chen, H Jiang… - Journal of …, 2008 - academic.oup.com
Abstract 3C-like protease (3CLpro) plays pivotal roles in the life cycle of severe acute
respiratory syndrome coronavirus (SARS-CoV) and only the dimeric protease is proposed …
respiratory syndrome coronavirus (SARS-CoV) and only the dimeric protease is proposed …
Identification of novel proteolytically inactive mutations in coronavirus 3C‐like protease using a combined approach
J Zhou, L Fang, Z Yang, S Xu, M Lv, Z Sun… - The FASEB …, 2019 - Wiley Online Library
Coronaviruses (CoVs) infect humans and multiple other animal species, causing highly
prevalent and severe diseases. 3C‐like proteases (3CLpros) from CoVs (also called main …
prevalent and severe diseases. 3C‐like proteases (3CLpros) from CoVs (also called main …
[HTML][HTML] Dissection study on the severe acute respiratory syndrome 3C-like protease reveals the critical role of the extra domain in dimerization of the enzyme: defining …
J Shi, Z Wei, J Song - Journal of Biological Chemistry, 2004 - ASBMB
The severe acute respiratory syndrome (SARS) 3C-like protease consists of two distinct
folds, namely the N-terminal chymotrypsin fold containing the domains I and II hosting the …
folds, namely the N-terminal chymotrypsin fold containing the domains I and II hosting the …
A new lead for nonpeptidic active-site-directed inhibitors of the severe acute respiratory syndrome coronavirus main protease discovered by a combination of …
U Kaeppler, N Stiefl, M Schiller, R Vicik… - Journal of medicinal …, 2005 - ACS Publications
The coronavirus main protease, Mpro, is considered to be a major target for drugs suitable
for combating coronavirus infections including severe acute respiratory syndrome (SARS) …
for combating coronavirus infections including severe acute respiratory syndrome (SARS) …
Mechanism for controlling the dimer-monomer switch and coupling dimerization to catalysis of the severe acute respiratory syndrome coronavirus 3C-like protease
J Shi, J Sivaraman, J Song - Journal of virology, 2008 - Am Soc Microbiol
Unlike 3C protease, the severe acute respiratory syndrome coronavirus (SARS-CoV) 3C-like
protease (3CLpro) is only enzymatically active as a homodimer and its catalysis is under …
protease (3CLpro) is only enzymatically active as a homodimer and its catalysis is under …
[HTML][HTML] Mutation of Gly-11 on the dimer interface results in the complete crystallographic dimer dissociation of severe acute respiratory syndrome coronavirus 3C-like …
S Chen, T Hu, J Zhang, J Chen, K Chen, J Ding… - Journal of biological …, 2008 - ASBMB
SARS-CoV 3C-like protease (3CL pro) is an attractive target for anti-severe acute respiratory
syndrome (SARS) drug discovery, and its dimerization has been extensively proved to be …
syndrome (SARS) drug discovery, and its dimerization has been extensively proved to be …
[HTML][HTML] Crystal structure of the papain-like protease of MERS coronavirus reveals unusual, potentially druggable active-site features
Abstract The Middle-East Respiratory Syndrome coronavirus (MERS-CoV) causes severe
acute pneumonia and renal failure. The MERS-CoV papain-like protease (PL pro) is a …
acute pneumonia and renal failure. The MERS-CoV papain-like protease (PL pro) is a …
Structure-based drug design and structural biology study of novel nonpeptide inhibitors of severe acute respiratory syndrome coronavirus main protease
IL Lu, N Mahindroo, PH Liang, YH Peng… - Journal of medicinal …, 2006 - ACS Publications
Severe acute respiratory syndrome coronavirus (SARS-CoV) main protease (Mpro), a
protein required for the maturation of SARS-CoV, is vital for its life cycle, making it an …
protein required for the maturation of SARS-CoV, is vital for its life cycle, making it an …