Despite recent advances in analytical and computational chemistry, lipid identification remains a significant challenge in lipidomics. Ion-mobility spectrometry provides an accurate …
Ion mobility—mass spectrometry (IM-MS) has showed great application potential for lipidomics. However, IM-MS based lipidomics is significantly restricted by the available …
DH Ross, JH Cho, R Zhang, KM Hines… - Analytical Chemistry, 2020 - ACS Publications
Comprehensive profiling of lipid species in a biological sample, or lipidomics, is a valuable approach to elucidating disease pathogenesis and identifying biomarkers. Currently, a …
Z Zhou, J Tu, ZJ Zhu - Current Opinion in Chemical Biology, 2018 - Elsevier
Highlights•Ion mobility–mass spectrometry (IM–MS) supports the metabolomics and lipidomics applications.•Collision cross-section (CCS) value is a valuable physiochemical …
BS Rose, JC May, AR Reardon… - Journal of the American …, 2022 - ACS Publications
Structures for lossless ion manipulation-based high-resolution ion mobility (HRIM) interfaced with mass spectrometry has emerged as a powerful tool for the separation and analysis of …
H Zhang, M Luo, H Wang, F Ren, Y Yin… - Analytical …, 2023 - ACS Publications
The development of ion mobility–mass spectrometry (IM–MS) has revolutionized the analysis of small molecules, such as metabolomics, lipidomics, and exposome studies. The …
J Tu, Z Zhou, T Li, ZJ Zhu - TrAC Trends in Analytical Chemistry, 2019 - Elsevier
Lipids represent an important class of biomolecules, and play numerous roles in physiological and pathological processes and activates. The enormous chemical and …
Identification of unknowns is a bottleneck for large-scale untargeted analyses like metabolomics or drug metabolite identification. Ion mobility-mass spectrometry (IM-MS) …
Collision cross section (CCS) measurement of lipids using traveling wave ion mobility-mass spectrometry (TWIM-MS) is of high interest to the lipidomics field. However, currently …