Hearing loss impacts the quality of life and affects communication resulting in social isolation
and reduced well-being. Despite its impact on society and economy, no therapies for age …

Severe hearing loss or deafness is often caused by cochlear hair cell loss and can be
mitigated by a cochlear implant (CI). CIs target the auditory nerve, consisting of spiral …

Nerve growth factor (NGF) is a neurotrophic factor that modulates survival and differentiation
of neural stem cells (NSCs). We investigated the function of NGF in promoting growth and …

Currently, there are no approved medicines available for the treatment of hearing loss.
However, research over the past two decades has contributed to a growing understanding of …

Neurotrophins (NTs) are pleiotropic molecules that can exert a variety of function in both the
central and peripheral nervous systems, modulating survival, development and function of …

Age‐related hearing loss (ARHL) is the most prevalent sensory deficit in the elderly. This
progressive pathology often has psychological and medical comorbidities, including social …

Sensorineural hearing loss is irreversible and is associated with the loss of spiral ganglion
neurons (SGNs) and sensory hair cells within the inner ear. Improving spiral ganglion …

Degeneration of spiral ganglion neurons (SGNs) and hair cells in the cochlea induced by
aging, injury, ototoxic drugs, acoustic trauma, and various diseases is the major cause of …

Severe to profound deafness is most often secondary to a loss of or injury to cochlear
mechanosensory cells, and there is often an associated loss of the peripheral auditory …

As key factors in the development and maintenance of the auditory system, neurotrophins
can prevent auditory neuron degeneration when applied within three to five days of …