The immune response to COVID‐19: Does sex matter?

JQ Ho, MR Sepand, B Bigdelou, T Shekarian… - …, 2022 - Wiley Online Library
Abstract The coronavirus disease 2019 (COVID‐19) pandemic has created unprecedented
challenges worldwide. Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) …

[HTML][HTML] What's sex got to do with COVID-19? Gender-based differences in the host immune response to coronaviruses

N Gadi, SC Wu, AP Spihlman, VR Moulton - Frontiers in immunology, 2020 - frontiersin.org
The novel severe acute respiratory syndrome coronavirus 2, the cause of the coronavirus
disease 2019 (COVID-19) pandemic, has ravaged the world, with over 22 million total cases …

[HTML][HTML] Implications of sex differences in immunity for SARS-CoV-2 pathogenesis and design of therapeutic interventions

MJ Bunders, M Altfeld - Immunity, 2020 - cell.com
Men present more frequently with severe manifestations of coronavirus disease 2019
(COVID-19) and are at higher risk for death. The underlying mechanisms for these …

Immune mechanisms associated with sex-based differences in severe COVID-19 clinical outcomes

CG Arnold, A Libby, A Vest, A Hopkinson… - Biology of sex …, 2022 - Springer
Background Although biological males and females are equally likely to become infected
with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), evidence has …

Sex differences in the immune response to acute COVID-19 respiratory tract infection

S Qi, C Ngwa, DA Morales Scheihing… - Biology of sex …, 2021 - Springer
Background Sex differences in COVID-19 are increasingly recognized globally. Although
infection rates are similar between the sexes, men have more severe illness. The …

Molecular and biological mechanisms underlying gender differences in COVID-19 severity and mortality

Z Wehbe, SH Hammoud, HM Yassine… - Frontiers in …, 2021 - frontiersin.org
Globally, over two million people have perished due to the recent pandemic caused by
SARS-CoV-2. The available epidemiological global data for SARS-CoV-2 portrays a higher …

Considering how biological sex impacts immune responses and COVID-19 outcomes

EP Scully, J Haverfield, RL Ursin… - Nature Reviews …, 2020 - nature.com
A male bias in mortality has emerged in the COVID-19 pandemic, which is consistent with
the pathogenesis of other viral infections. Biological sex differences may manifest …

Sex differences in immunity to viral infections

H Jacobsen, SL Klein - Frontiers in immunology, 2021 - frontiersin.org
The ongoing COVID-19 pandemic has increased awareness about sex-specific differences
in immunity and outcomes following SARS-CoV-2 infection. Strong evidence of a male bias …

Sex-related differences in innate and adaptive immune responses to SARS-CoV-2

S Agrawal, J Salazar, TM Tran, A Agrawal - Frontiers in Immunology, 2021 - frontiersin.org
Coronavirus disease 2019 (COVID-19) exhibits a sex bias with males showing signs of more
severe disease and hospitalizations compared with females. The mechanisms are not clear …

Higher mortality of COVID-19 in males: sex differences in immune response and cardiovascular comorbidities

LA Bienvenu, J Noonan, X Wang… - Cardiovascular …, 2020 - academic.oup.com
The high mortality rate of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
infection is a critical concern of the coronavirus disease 2019 (COVID-19) pandemic …