Secondary and tertiary alicyclic amines are widely found in pharmaceuticals and
environmental compounds. The formation of iminium ions as reactive intermediates in the …

Cytochrome P450-mediated bioactivation of drugs to reactive metabolites has been reported
to be the first step in many adverse drug reactions. Metabolic activation of cyclic tertiary …

The evidence implicating the formation of iminium ions as reactive intermediates in the
metabolism of alicyclic amines has been reviewed. The mechanism of formation of iminium …

Heterocyclic amines (HAs) are mutagenic compounds to which humans are regularly
exposed through diet. Due to the high complexity of the sample matrix and the low level of …

A rapid and facile tandem solvent solid phase extraction method was established to isolate
the heterocyclic aromatic amines (HAAs) 2-amino-3, 8-dimethylimidazo [4, 5-f] quinoxaline …

A need still exists for a liquid chromatography/tandem mass spectrometry (LC/MS/MS)
method that can detect broad classes of glutathione (GSH) conjugates and provide …

The present study describes a new analytical approach for the detection and
characterization of GSH-trapped reactive metabolites using multiple reaction monitoring …

Primary and secondary amines, including amino acids, biogenic amines, hormones,
neurotransmitters, and plant siderophores, are readily derivatized with 6-aminoquinolyl-N …

Cigarette smoking significantly increases the risk of cancer and cardiovascular diseases as
well as premature death. Aromatic amines (AAs) such as o-toluidine, 2-aminonaphthalene …

The presence of aromatic amines in the environment has been in the focus of research, as
many of these compounds are known or suspected mutagens and carcinogens. To facilitate …