Background Systemic inflammation is associated with skeletal muscle atrophy and
metabolic dysfunction. Although the nucleotide‐binding oligomerization domain‐like …

Low-grade chronic inflammation plays a pivotal role in the pathogenesis of insulin
resistance (IR), and skeletal muscle has a central role in this condition. NLRP3 …

Rationale: The inflammasome has been widely reported to be involved in various
myopathies, but little is known about its role in denervated muscle. Here, we explored the …

Over the last decade, innate immune system receptors and sensors called inflammasomes
have been identified to play key pathological roles in the development and progression of …

The mechanisms underpinning decreased skeletal muscle strength and slowing of
movement during aging are ill-defined.“Inflammaging,” increased inflammation with …

Inclusion body myositis (IBM) is a chronic, mostly treatment-resistant, inflammatory myopathy
with a pathology that centers around specific interactions between inflammation and protein …

Skeletal muscle atrophy is a common complication in survivors of sepsis, which affects the
respiratory and motor functions of patients, thus severely impacting their quality of life and …

Sarcopenia is defined as the age-related loss of skeletal muscle mass, quality, and strength.
The pathophysiological mechanisms underlying sarcopenia are still not completely …

Among multiple mechanisms, low-grade inflammation is critical for the development of
insulin resistance as a feature of type 2 diabetes. The nucleotide-binding oligomerization …

Inflammasomes are molecular hubs that are assembled and activated by a host in response
to various microbial and non-microbial stimuli and play a pivotal role in maintaining tissue …