The genetics of complex disease produce alterations in the molecular interactions of cellular
pathways whose collective effect may become clear through the organized structure of …

Alzheimer's disease (AD) is a debilitating neurodegenerative disorder affecting millions of
elderly individuals worldwide. Advances in the genetics of AD have led to new levels of …

Here, we report proteomic analyses of 129 human cortical tissues to define changes
associated with the asymptomatic and symptomatic stages of Alzheimer's disease (AD) …

Integrative gene network approaches enable new avenues of exploration that implicate
causal genes in sporadic late-onset Alzheimer's disease (LOAD) pathogenesis, thereby …

Complex biological systems are organized across various spatiotemporal scales with
particular scientific disciplines dedicated to the study of each scale (eg genetics, molecular …

Genetic studies in late-onset Alzheimer disease (LOAD) are aimed at identifying core
disease mechanisms and providing potential biomarkers and drug candidates to improve …

Asymptomatic and symptomatic Alzheimer's disease (AD) subjects may present with
equivalent neuropathological burdens but have significantly different antemortem cognitive …

Abstract Background Oligodendrocytes (OLs) and myelin are critical for normal brain
function and have been implicated in neurodegeneration. Several lines of evidence …

Neurodegenerative diseases are rarely caused by a mutation in a single gene but rather
influenced by a combination of genetic, epigenetic and environmental factors. Emerging …

Background Alzheimer's disease (AD) is the most common form of dementia, characterized
by progressive cognitive impairment and neurodegeneration. However, despite extensive …