Unraveling the Role of Autophagy in Cancer Page 1 ©2005 LANDES BIOSCIENCE. DO
NOT DISTRIBUTE. www.landesbioscience.com Autophagy 65 [Autophagy 2:2, 65-66, April/May/June …

Macroautophagy is mainly considered to be a mechanism for the bulk degradation of the
cytoplasm in times of nutrient depletion. However, growing evidence suggests that …

Autophagy is an evolutionarily conserved, catabolic process that involves the entrapment of
cytoplasmic components within characteristic vesicles for their delivery to and degradation …

Allelic loss of the essential autophagy gene beclin1 occurs in human cancers and renders
mice tumor-prone suggesting that autophagy is a tumor-suppression mechanism. While …

Autophagy is an evolutionarily conserved catabolic pathway that has multiple roles in
carcinogenesis and cancer therapy. It can inhibit the initiation of tumorigenesis through …

Autophagy is a highly regulated catabolic process that involves lysosomal degradation of
proteins and organelles, mostly mitochondria, for the maintenance of cellular homeostasis …

Autophagy is intricately linked with many intracellular signaling pathways, particularly
nutrient-sensing mechanisms and cell death signaling cascades. In cancer, the roles of …

As a conserved cellular degradative pathway in eukaryotes, autophagy relieves cells from
various types of stress. There are different forms of autophagy, and the ongoing studies of …

Autophagy is a well-established mechanism to degrade intracellular components and
provide a nutrient source to promote survival of cells in metabolic distress. Such stress can …

Autophagy is an important catabolic process that delivers cytoplasmic material to the
lysosome for degradation. Autophagy promotes cell survival by elimination of damaged …