Crucial transitions in cancer—including tumor initiation, local expansion, metastasis, and
therapeutic resistance—involve complex interactions between cells within the dynamic …

Cancer is a major cause of global mortality underpinned by genomic and epigenomic
derangements. Here, we highlight the importance of multimodal data integration in …

The Cancer Genome Atlas: Creating Lasting Value beyond Its Data Page 1 Leading Edge
Commentary The Cancer Genome Atlas: Creating Lasting Value beyond Its Data Carolyn …

The spatial organization of the tumor microenvironment has a profound impact on biology
and therapy response. Here, we perform an integrative single-cell and spatial transcriptomic …

Many malignancies display heterogeneous features that support cancer progression.
Emerging high-resolution methods provide a view of heterogeneity that recognizes the …

Understanding the earliest molecular and cellular events associated with cancer initiation
remains a key bottleneck to transforming our approach to cancer prevention and detection …

Abstract Purpose: The Cancer Genome Atlas data resources represent an opportunity to
explore commonalities across cancer types involving multiple molecular levels, but tumor …

Summary The Cancer Genome Atlas (TCGA) has catalyzed systematic characterization of
diverse genomic alterations underlying human cancers. At this historic junction marking the …

Digital pathology allows computerized analysis of tumor ecosystem using whole slide
images (WSIs). Here, we present single-cell morphological and topological profiling (sc …

Transformative technologies are enabling the construction of three-dimensional maps of
tissues with unprecedented spatial and molecular resolution. Over the next seven years, the …