Recent advances in the generation of kidney organoids and the culture of primary nephron
progenitors from mouse and human have been based on knowledge of the molecular basis …

Recent advances in the generation of kidney organoids and the culture of primary nephron
progenitors from mouse and human have been based on knowledge of the molecular basis …

The mammalian kidney develops through reciprocal interactions between the ureteric bud
and the metanephric mesenchyme to give rise to the entire collecting system and the …

Recent advances in stem cell biology have enabled the generation of kidney organoids in
vitro, and further maturation of these organoids is observed after experimental …

Recent advances in our capacity to differentiate human pluripotent stem cells to human
kidney tissue are moving the field closer to novel approaches for renal replacement. Such …

Human kidney function is underpinned by approximately 1,000,000 nephrons, although the
number varies substantially, and low nephron number is linked to disease. Human kidney …

Development of the metanephric kidney is strongly dependent on complex signaling
pathways and cell–cell communication between at least four major progenitor cell …

The functional unit of the kidney is the nephron. During its organogenesis, the mammalian
metanephric kidney generates thousands of nephrons over a protracted period of fetal life …

The reciprocal interactions among the different embryonic kidney progenitor populations lay
the basis for proper kidney organogenesis. During kidney development, three types of …

Nephron formation continues throughout kidney morphogenesis in both mice and humans.
Lineage tracing studies in mice identified a self‐renewing Six2‐expressing nephron …