IDH mutation impairs histone demethylation and results in a block to cell differentiation
Recurrent mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 have been identified in
gliomas, acute myeloid leukaemias (AML) and chondrosarcomas, and share a novel …
gliomas, acute myeloid leukaemias (AML) and chondrosarcomas, and share a novel …
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
Mutations in the enzyme cytosolic isocitrate dehydrogenase 1 (IDH1) are a common feature
of a major subset of primary human brain cancers. These mutations occur at a single amino …
of a major subset of primary human brain cancers. These mutations occur at a single amino …
IDH1 (R132H) mutation increases murine haematopoietic progenitors and alters epigenetics
Mutations in the IDH1 and IDH2 genes encoding isocitrate dehydrogenases are frequently
found in human glioblastomas and cytogenetically normal acute myeloid leukaemias (AML) …
found in human glioblastomas and cytogenetically normal acute myeloid leukaemias (AML) …
An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells
The recent discovery of mutations in metabolic enzymes has rekindled interest in harnessing
the altered metabolism of cancer cells for cancer therapy. One potential drug target is …
the altered metabolism of cancer cells for cancer therapy. One potential drug target is …
Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation
F Wang, J Travins, B DeLaBarre, V Penard-Lacronique… - Science, 2013 - science.org
A number of human cancers harbor somatic point mutations in the genes encoding isocitrate
dehydrogenases 1 and 2 (IDH1 and IDH2). These mutations alter residues in the enzyme …
dehydrogenases 1 and 2 (IDH1 and IDH2). These mutations alter residues in the enzyme …
(R)-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible
JA Losman, RE Looper, P Koivunen, S Lee… - Science, 2013 - science.org
Mutations in IDH1 and IDH2, the genes coding for isocitrate dehydrogenases 1 and 2, are
common in several human cancers, including leukemias, and result in overproduction of the …
common in several human cancers, including leukemias, and result in overproduction of the …
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation
The identification of succinate dehydrogenase (SDH), fumarate hydratase (FH) and
isocitrate dehydrogenase (IDH) mutations in human cancers has rekindled the idea that …
isocitrate dehydrogenase (IDH) mutations in human cancers has rekindled the idea that …
Rapid conversion of mutant IDH1 from driver to passenger in a model of human gliomagenesis
TCA Johannessen, J Mukherjee, P Viswanath… - Molecular Cancer …, 2016 - AACR
Missense mutations in the active site of isocitrate dehydrogenase 1 (IDH1) biologically and
diagnostically distinguish low-grade gliomas and secondary glioblastomas from primary …
diagnostically distinguish low-grade gliomas and secondary glioblastomas from primary …
IDH1 Mutation Induces Reprogramming of Pyruvate Metabolism
JL Izquierdo-Garcia, P Viswanath, P Eriksson, L Cai… - Cancer research, 2015 - AACR
Abstract Mutant isocitrate dehydrogenase 1 (IDH1) catalyzes the production of 2-
hydroxyglutarate but also elicits additional metabolic changes. Levels of both glutamate and …
hydroxyglutarate but also elicits additional metabolic changes. Levels of both glutamate and …
Identification of additional IDH mutations associated with oncometabolite R (−)-2-hydroxyglutarate production
Mutations in cytosolic isocitrate dehydrogenase 1 (IDH1) or its mitochondrial homolog IDH2
can lead to R (−)-2-hydroxyglutarate (2HG) production. To date, mutations in three active site …
can lead to R (−)-2-hydroxyglutarate (2HG) production. To date, mutations in three active site …