Microglial research has advanced considerably in recent decades yet has been constrained
by a rolling series of dichotomies such as" resting versus activated" and" M1 versus M2." …

Microglia are the resident immune effector cells of the central nervous system (CNS) rapidly
reacting to any perturbation in order to maintain CNS homeostasis. Although their …

Microglia are brain‐resident macrophages forming the first active immune barrier in the
central nervous system. They fulfill multiple functions across development and adulthood …

Microglia, the tissue macrophages of the brain, have under healthy conditions a resting
phenotype that is characterized by a ramified morphology. With their fine processes …

Microglia, the resident myeloid cells in the central nervous system (CNS) play critical roles in
shaping the brain during development, responding to invading pathogens, and clearing …

Microglia were first recognized as a distinct cell population in the CNS one century ago. For
a long time, they were primarily considered to be phagocytes responsible for removing …

Microglia serve in the surveillance and maintenance, protection and restoration of the
central nervous system (CNS) homeostasis. By their parenchymal location they differ from …

As extremely sensitive immune cells, microglia act as versatile watchdogs of the central
nervous system (CNS) that tightly control tissue homeostasis. Therefore, microglial activation …

Originally hypothesized to function solely as immunologic responders within the central
nervous system (CNS), emerging evidence has revealed that microglia have more complex …

Inflammatory processes and microglia activation accompany most of the pathophysiological
diseases in the central nervous system. It is proven that glial pathology precedes and even …