Evaluation of pro-apoptotic potential of taxifolin against liver cancer

SS Butt, K Khan, Y Badshah, M Rafiq, M Shabbir - PeerJ, 2021 - peerj.com
Liver cancer is the second most common cause of cancer-induced deaths worldwide. Liver
cirrhosis and cancer are a consequence of the abnormal angio-architecture formation of …

[HTML][HTML] Pharmacological basis and new insights of taxifolin: A comprehensive review

A Das, R Baidya, T Chakraborty, AK Samanta… - Biomedicine & …, 2021 - Elsevier
The pharmacological characteristics of phytochemicals have prompted a lot of interest in
their application in disease management. Due to the high incidence of cancer related …

Taxifolin suppresses the malignant progression of gastric cancer by regulating the AhR/CYP1A1 signaling pathway

J Xie, Y Pang, X Wu - International Journal of …, 2021 - spandidos-publications.com
The development of novel approaches for the treatment of gastric cancer is of utmost
importance. Taxifolin (Tax) has been reported to possess biological activities against a …

[PDF][PDF] Taxifolin inhibits the development of scar cell carcinoma by inducing apoptosis, cell cycle arrest, and suppression of PI3K/AKT/mTOR pathway

W Zhou, Z Liu, M Wang, D Chen, L Zhou, L Guo - J. Buon, 2019 - jbuon.com
Purpose: Plant metabolites have gained considerable attention as the anticancer agents
over the last few decades. Previous studies have indicated the potential of taxifolin as an …

Plant flavonoid taxifolin inhibits the growth, migration and invasion of human osteosarcoma cells

X Chen, N Gu, C Xue, BR Li - Molecular medicine …, 2018 - spandidos-publications.com
The aim of the present study was to investigate the anti-cancer effects of the natural plant
flavonoid, taxifolin, on human osteosarcoma cancer cells. Taxifolin was demonstrated to …

[HTML][HTML] The anti-tumor effect of taxifolin on lung cancer via suppressing stemness and epithelial-mesenchymal transition in vitro and oncogenesis in nude mice

R Wang, X Zhu, Q Wang, X Li, E Wang… - Annals of …, 2020 - ncbi.nlm.nih.gov
Background Taxifolin is a natural flavonoid with anti-oxidant and anti-proliferative properties.
In this study, we investigated the stemness-related inhibitory effects of taxifolin in two lung …

Taxifolin inhibits breast cancer cells proliferation, migration and invasion by promoting mesenchymal to epithelial transition via β-catenin signaling

J Li, L Hu, T Zhou, X Gong, R Jiang, H Li, G Kuang… - Life sciences, 2019 - Elsevier
Aim To investigate the effects and underlying mechanisms of taxifolin on proliferation,
migration and invasion of highly aggressive breast cancer in vitro and in vivo. Main methods …

[HTML][HTML] Taxifolin binds with LXR (α & β) to attenuate DMBA-induced mammary carcinogenesis through mTOR/Maf-1/PTEN pathway

MW Haque, P Bose, MUM Siddique, P Sunita… - Biomedicine & …, 2018 - Elsevier
Abstract Aim 7, 12-dimethylbenz (a) anthracene (DMBA), a PAH derivative initializes
cascades of signaling events that alters a variety of enzymes responsible for lipid and …

β-Thujaplicin induces autophagic cell death, apoptosis, and cell cycle arrest through ROS-mediated Akt and p38/ERK MAPK signaling in human hepatocellular …

G Zhang, J He, X Ye, J Zhu, X Hu, M Shen, Y Ma… - Cell death & …, 2019 - nature.com
Hepatocellular carcinoma (HCC), a common liver malignancy worldwide, has high morbidity
and mortality. β-Thujaplicin, a tropolone derivative, has been used in some health-care …

Potential anti-liver cancer targets and mechanisms of kaempferitrin based on network pharmacology, molecular docking and experimental verification

S Zhou, H Zhang, J Li, W Li, M Su, Y Ren, F Ge… - Computers in Biology …, 2024 - Elsevier
Aim Kaempferitrin is an active component in Chenopodium ambrosioides, showing
medicinal functions against liver cancer. This study aimed to identify the potential targets …