[PDF][PDF] The newly emerged SARS-like coronavirus HCoV-EMC also has an" Achilles' heel": current effective inhibitor targeting a 3C-like protease
Z Ren, L Yan, N Zhang, Y Guo, C Yang, Z Lou… - Protein & cell, 2013 - dunapress.com
From the global outbreak of SARS-CoV caused infection disease in 2003, coronaviruses
(CoVs) are known to be a great threat to the human health. Recently, a new SARS-like …
(CoVs) are known to be a great threat to the human health. Recently, a new SARS-like …
[HTML][HTML] Structure of main protease from human coronavirus NL63: insights for wide spectrum anti-coronavirus drug design
Abstract First identified in The Netherlands in 2004, human coronavirus NL63 (HCoV-NL63)
was found to cause worldwide infections. Patients infected by HCoV-NL63 are typically …
was found to cause worldwide infections. Patients infected by HCoV-NL63 are typically …
Potential of coronavirus 3C-like protease inhibitors for the development of new anti-SARS-CoV-2 drugs: Insights from structures of protease and inhibitors
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), similar to SARS-CoV and
Middle East respiratory syndrome coronavirus (MERS-CoV), which belong to the same …
Middle East respiratory syndrome coronavirus (MERS-CoV), which belong to the same …
3C-like protease inhibitors block coronavirus replication in vitro and improve survival in MERS-CoV–infected mice
Pathogenic coronaviruses are a major threat to global public health, as exemplified by
severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory …
severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory …
[HTML][HTML] Coronaviruses—drug discovery and therapeutic options
In humans, infections with the human coronavirus (HCoV) strains HCoV-229E, HCoV-OC43,
HCoV-NL63 and HCoV-HKU1 usually result in mild, self-limiting upper respiratory tract …
HCoV-NL63 and HCoV-HKU1 usually result in mild, self-limiting upper respiratory tract …
[HTML][HTML] Potential inhibitors against 2019-nCoV coronavirus M protease from clinically approved medicines
X Liu, XJ Wang - Journal of Genetics and Genomics, 2020 - ncbi.nlm.nih.gov
Coronaviruses, members of the family Coronaviridae and subfamily Coronavirinae, are
enveloped positive-strand RNA viruses which have spikes of glycoproteins projecting from …
enveloped positive-strand RNA viruses which have spikes of glycoproteins projecting from …
Structural basis of main proteases of coronavirus bound to drug candidate PF-07304814
J Li, C Lin, X Zhou, F Zhong, P Zeng… - Journal of molecular …, 2022 - Elsevier
New variants of the severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2)
emerged and spread rapidly all over the world, which strongly supports the need for …
emerged and spread rapidly all over the world, which strongly supports the need for …
Structures of two coronavirus main proteases: implications for substrate binding and antiviral drug design
Coronaviruses (CoVs) can infect humans and multiple species of animals, causing a wide
spectrum of diseases. The coronavirus main protease (Mpro), which plays a pivotal role in …
spectrum of diseases. The coronavirus main protease (Mpro), which plays a pivotal role in …
Overview of antiviral drug candidates targeting coronaviral 3C‐like main proteases
CC Chen, X Yu, CJ Kuo, J Min, S Chen, L Ma… - The FEBS …, 2021 - Wiley Online Library
Coronaviruses (CoVs) are positive single‐stranded RNA viruses that cause severe
respiratory syndromes in humans, including severe acute respiratory syndrome (SARS) and …
respiratory syndromes in humans, including severe acute respiratory syndrome (SARS) and …
Synthesis, crystal structure, structure− activity relationships, and antiviral activity of a potent SARS coronavirus 3CL protease inhibitor
S Yang, SJ Chen, MF Hsu, JD Wu… - Journal of medicinal …, 2006 - ACS Publications
A potent SARS coronavirus (CoV) 3CL protease inhibitor (TG-0205221, K i= 53 nM) has
been developed. TG-0205221 showed remarkable activity against SARS CoV and human …
been developed. TG-0205221 showed remarkable activity against SARS CoV and human …