STUDY HYPOTHESIS Is it possible to immunologically activate human cervical epithelial
cells to produce antiviral factors that inhibit herpes simplex virus type 2 (HSV-2) replication …

Herpes simplex virus type 2 (HSV-2) is associated with a variety of diseases that are health
problems worldwide. Our early study showed that lambda-interferons (IFN-λs), induced by …

This study has shown that IFN-α/β signaling is crucial for combating primary herpes simplex
virus type 2 (HSV-2) infection and for responding to immunotherapy using ligands to TLR3, 7 …

Our previous studies demonstrated that HSV-2 infection up-regulates TLR4 expression and
induces NF-kB activity, thereby facilitating innate immune response in human cervical …

The innate immune system has evolved to recognize invading pathogens through pattern
recognition receptors (PRRs). Among PRRs, Toll like receptors (TLRs 3, 7/8, 9) and RIG-I …

Genital epithelial cells (GECs) are the first line of mucosal defense against sexually
transmitted infections. We exploited the ability of GECs to mount innate immune responses …

Herpes simplex virus type 2 (HSV-2) is one of the most common sexually transmitted
pathogens worldwide. The host immune response induced by viral infection is cell-type …

Objective The pathway by which herpes simplex virus 2 (HSV2) triggers the innate immune
system in the urogenital system has not as yet been fully elucidated. In this study, we aimed …

Viruses that establish persistent infections have evolved numerous strategies to evade host
innate antiviral responses. We functionally assessed the role of herpes simplex virus type 2 …

Innate antiviral immunity, particularly at mucosal surfaces, has a critical role in early control
of viral infections. Both type I interferons (IFNs) and interleukin‐15 (IL‐15) are essential …