Differential susceptibilities of mice genomically deleted of CD4 and CD8 to infections with Trypanosoma cruzi or Trypanosoma brucei

ME Rottenberg, M Bakhiet, T Olsson… - Infection and …, 1993 - Am Soc Microbiol
The role of CD4+ and CD8+ T cells in the surveillance of Trypanosoma cruzi or
Trypanosoma brucei brucei was studied in mice which lacked CD4 or CD8 molecules and …

Outcome of infection with different strains of Trypanosoma cruzi in mice lacking CD4 and/or CD8

ME Rottenberg, A Riarte, L Sporrong, J Altcheh… - Immunology …, 1995 - Elsevier
Mice lacking CD4 and/or CD8 gene expression, generated by embryonic stem-cell
technology, were used to study the role of CD4+ and CD8+ cells in the resistance to the …

Most parasite‐specific CD8+ cells in Trypanosoma cruzi‐infected chronic mice are down‐regulated for T‐cell receptor‐αβ and CD8 molecules

MG Grisotto, MR D'Império Lima, CRF Marinho… - …, 2001 - Wiley Online Library
The present study shows that CD8+ T lymphocytes expressing low levels of T‐cell receptor
(TCR) αβ, CD8 and CD3 accumulate in the spleen, blood, peritoneum and liver, but not in …

Depletion of CD8+ T cells increases susceptibility and reverses vaccine-induced immunity in mice infected with Trypanosoma cruzi.

RL Tarleton - Journal of immunology (Baltimore, Md.: 1950), 1990 - journals.aai.org
The role of CD8+ T cells in immune control of Trypanosoma cruzi infection in mice was
examined by using in vivo depletion of CD8+ T cells with antibodies. Both the resistant …

[引用][C] The role of T cells in Trypanosoma cruzi infections

RL Tarleton - Parasitology today, 1995 - Elsevier
Trypanosoma cruzi Infections l thank Dr Kierszenbaum for highlighting the complexities of
the participation of CD8* T cells in immunity and patho-genesis in Trypanosoma cruzi …

Predominance of CD4 Th1 and CD8 Tc1 cells revealed by characterization of the cellular immune response generated by immunization with a DNA vaccine …

MM Rodrigues, M Ribeirão… - Infection and …, 1999 - Am Soc Microbiol
Immunization with a plasmid DNA containing the gene encoding the catalytic domain of
trans-sialidase (TS) elicits protective immune responses against experimental Trypanosoma …

Trypanosoma cruzi infection in MHC-deficient mice: further evidence for the role of both class I- and class II-restricted T cells in immune resistance and disease

RL Tarleton, MJ Grusby, M Postan… - International …, 1996 - academic.oup.com
The role of T cell populations in immune control of Trypanosoma cruzi infection and
subsequent development of disease has been examined using gene knockout mice …

Development of resistance to Trypanosoma cruzi in mice depends on a viable population of L3T4+ (CD4+) T lymphocytes

FG Araujo - Infection and Immunity, 1989 - Am Soc Microbiol
Mice injected with monoclonal antibody to the L3T4+ (CD4+) cell membrane surface
glycoprotein of T lymphocytes and immunized with antigens of Trypanosoma cruzi had …

Limited Role for CD4+ T-Cell Help in the Initial Priming of Trypanosoma cruzi-Specific CD8+ T Cells

A Padilla, D Xu, D Martin, R Tarleton - Infection and immunity, 2007 - Am Soc Microbiol
Immune control of the protozoan parasite Trypanosoma cruzi requires the activation of both
CD4+ and CD8+ T cells. We recently identified two T. cruzi trans-sialidase peptides that are …

[HTML][HTML] Experimental Trypanosoma cruzi infection alters the shaping of the central and peripheral T-cell repertoire

DA Mendes-da-Cruz, J de Meis… - Microbes and …, 2003 - Elsevier
We investigated the thymic and peripheral T-lymphocyte subsets in BALB/c mice undergoing
acute or chronic Trypanosoma cruzi infection, in terms of expression of particular Vβ …