More than 800 million people suffer from kidney disease. Genetic studies and follow-up
animal models and cell biological experiments indicate the key role of proximal tubule …

Mitochondrial dysfunction has gained recognition as a contributing factor in many diseases.
The kidney is a kind of organ with high energy demand, rich in mitochondria. As such …

The kidney is a vital organ that demands an extraordinary amount of energy to actively
maintain the body's metabolism, plasma hemodynamics, electrolytes and water …

Recent advances have led to a greater appreciation of how mitochondrial dysfunction
contributes to diverse acute and chronic pathologies. Indeed, mitochondria have received …

Mitochondria are a class of dynamic organelles that constantly undergo fission and fusion.
Mitochondrial dynamics is governed by a complex molecular machinery and finely tuned by …

Chronic kidney disease (CKD) is associated with a variety of distinct disease processes that
permanently change the function and structure of the kidney across months or years. CKD is …

The kidney requires a large number of mitochondria to remove waste from the blood and
regulate fluid and electrolyte balance. Mitochondria provide the energy to drive these …

Mitochondria are heterogeneous and highly dynamic organelles, playing critical roles in
adenosine triphosphate (ATP) synthesis, metabolic modulation, reactive oxygen species …

Disruption of mitochondrial biosynthesis or dynamics, or loss of control over mitochondrial
regulation leads to a significant alteration in fuel preference and metabolic shifts that …

Mitochondria are essential for the activity, function and viability of eukaryotic cells and
mitochondrial dysfunction is involved in the pathogenesis of acute kidney injury (AKI) and …